High-gain signal-on PEDOT:PSS organic photoelectrochemical transistor biosensing modulated by a MXene/MOFs/NiO Schottky heterojunction  

作　　者：Zheng Li Yi-Tong Xu Jin Hu Ting Wang Fang-Qing Liu Hong Zhou Guang-Xu Chen Peng Lin Wei-Wei Zhao Jing-Juan Xu Hong-Yuan Chen 

机构地区：[1]State Key Laboratory of Analytical Chemistry for Life Science,School of Chemistry and Chemical Engineering,Nanjing University,Nanjing,210023,China [2]Shenzhen Key Laboratory of Special Functional Materials&Guangdong Research Center for Interfacial Engineering of Functional Materials,College of Materials Science and Engineering,Shenzhen University,Shenzhen,518060,China [3]Shandong Key Laboratory of Biochemical Analysis,College of Chemistry and Molecular Engineering,Qingdao University of Science and Technology,Qingdao,266042,China [4]School of Environment and Energy,State Key Laboratory of Luminescent Materials and Devices,Guangdong Provincial Key Laboratory of Atmospheric Environment and Pollution Control,South China University of Technology,Guangzhou,510006,China

出　　处：《Science China Chemistry》2023年第2期578-585,共8页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(22034003,21974059,22174063);the Excellent Research Program of Nanjing University(ZYJH004);the State Key Laboratory of Analytical Chemistry for Life Science(5431ZZXM2203)。

摘　　要：Herein we report a high-gain signal-on poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)(PEDOT:PSS)organic electrochemical transistor(OECT)biosensing using an accumulation-mode PEDOT:PSS OECT modulated by a light-fueled MXene/MOFs/Ni O Schottky heterojunction.In such a system,the MXene/MOFs/Ni O Schottky heterojunction exhibited superior gating effect,as it not only enabled the fast-directional charge transfer but also guaranteed the maximal accessibility of the electrolyte to topped 2D MXene with large surface area.In linkage with a bi-enzyme cascade system,the quinone derivatives produced by the cascade reaction of alkaline phosphatase(ALP)and tyrosinase(TYR)could serve as effective electron acceptors for the representative Ti_(3)C_(2)/PCN-224/Ni O heterojunction,underpinning an innovative method for sensitive detection of ALP activity with a low detection limit of 0.001 U L^(-1).Remarkably,the as-developed system demonstrated a remarkable current gain as high as near 10^(4),which to our knowledge is the highest one among existing OECT biosensory devices.This work represents a generic protocol to develop the novel signal-on PEDOT:PSS OECT platform towards biochemical detection and beyond.

关 键 词：signal-on PEDOT:PSS organic electrochemical transistor BIOSENSING Schottky heterojunction 

分 类 号：O641.4[理学—物理化学]