基于温病古籍挖掘中医霍乱病的辨治规律  

Study on Traditional Chinese Medical treatment rules of cholera syndrome based on Data Mining of TCM classics

作　　者：贾紫涵 佟琳[1] 张磊[1] 陈广坤[1] 马艳 张宇 李想[1] 李鸿涛[1] JIA Zihan;TONG Lin;ZHANG Lei;CHEN Guangkun;MA Yan;ZHANG Yu;LI Xiang;LI Hongtao(Institute of Information on Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院中医药信息研究所,北京100700 [2]中国中医科学院中医临床基础医学研究所

出　　处：《环球中医药》2023年第1期13-20,共8页Global Traditional Chinese Medicine

基　　金：国家自然科学基金(82105055);《中华医藏》编纂项目(KJS-ZHYC-2020-016);中国中医科学院创新工程(CI2021A00507);中央级公益性科研院所基本科研业务费项目(ZZ13-YQ-130,ZZ13-YQ-131)。

摘　　要：目的探讨中医古籍中霍乱的辨证论治规律,为当代医家辨治本病提供思路。方法统计“温病古籍知识库”文献中陈述霍乱的理论内容,整理规范病因、病位、方药、治法相关内容并建立霍乱疾病数据库。运用数理统计法对霍乱的病因、病位、症状、治法、方剂、中药、出处进行频次、频率、累积频率分析;运用因子分析与聚类方法相结合分析找寻霍乱证候;运用关联规则挖掘探讨药物配伍及症状与中药间的关系。结果共计196条文献论及霍乱病因,以时行疫疠秽浊、饮食不节以及素体脾虚等病因为主;59条文献论及病位,其病位以胃、脾、肠为多见;232条文献论及症状,对症状进行聚类概括为亡阳证、干霍乱证、寒证霍乱、热证霍乱、湿热霍乱五类证候;114条文献论及治法,以芳香化浊为主法,以及外治法相配合使用;219条文献论及方剂,涉及方剂82种,中药185种,经统计白术、厚朴、茯苓、半夏、广藿香、陈皮、白芷、桔梗、大腹皮等药物出现频次较高,主要为利水渗湿、理气、清热类的药物。根据关联规则分析,药对支持度最高为白术-茯苓,其余依次为半夏-茯苓、广藿香-厚朴、半夏-厚朴、半夏-广藿香等,其配伍有化湿理气之功,具有霍乱病的治疗特色;从药团分析,半夏、厚朴、白术、茯苓、广藿香同时出现的频率大,与藿香正气散组成较吻合,藿香正气散及其加减为治疗霍乱常用方。结论本研究通过数据挖掘的方法挖掘温病古籍中霍乱病的辨证论治规律,可为中医临证诊治提供较为可靠的数据资料。古代医家对霍乱的辨证论治经验和防治措施对现代防疫治疫仍有现实意义,可为现代应对突发性传染病提供参考。Objective To discuss the rules of syndrome differentiation and treatment of cholera in the Knowledge base of ancient books on Febrile diseases,and provides ideas for doctors to diagnose and treat the disease from the perspective of traditional Chinese medicine.Methods Count the theoretical content of cholera stated in the literature of Knowledge base of ancient books on Febrile diseases,the related contents of etiology,disease locus,prescriptions and treatment were sorted out and standardized,and the cholera disease database was established.Using mathematical statistics to analyze the frequency,frequency and cumulative frequency of etiology,disease locus,symptoms,treatment,prescriptions,traditional Chinese medicine and source of cholera;using factor analysis to extract cholera symptom cluster;using cluster analysis to classify the causes of cholera and find the syndromes according to the classification results;Using association rule mining to explore the drug incompatibility,and the relationship between symptoms and traditional Chinese medicine.Results A total of 196 literatures discussed the etiology of cholera,and the main etiologies were epidemic disease,poor diet,plain body and spleen deficiency;59 literatures discussed the disease sites,and the most common sites were stomach,spleen and intestine;232 literatures discussed symptoms,and the symptoms were clustered and summarized into five types of syndromes:death Yang syndrome,dry cholera syndrome,cold cholera syndrome,heat cholera syndrome and damp-heat cholera syndrome;114 literatures discussed treatment methods,mainly aromatizing turbidity method,and external treatment method in combination;there were 219 articles on prescriptions,involving 82 kinds of prescriptions and 185 kinds of traditional Chinese medicine.According to statistics,Baizhu(Atractylodis macrocephalae rhizoma),Houpo(Magnoliae officinalis cortex),Fuling(Poria),Banxia(Pinelliae rhizoma),Guanghuoxiang(Pogostemonis herba),Chenpi(Citri reticulatae pericarpium),Baizhi(Angelicae dahuricae radix),Ji

关 键 词：霍乱 辨证论治 中医古籍 数据挖掘 用药规律 中医药 治疗 药对 

分 类 号：R254.7[医药卫生—中医内科学]