血清白细胞介素-10、白细胞介素-17水平预测重度子痫前期患者胎膜早破的临床研究  

Clinical Study of Serum and Interleukin-10 and Interleukin-17 Levels in Predicting Premature Rupture of Membranes in Patients with Severe Preeclampsia

作　　者：刘光虹[1] 张丽丽[1] 邵志萍 LIU Guang-hong;ZHANG Li-li;SHAO Zhi-ping(Department of Obstetrics and Gynecology,Zhengzhou People’s Hospital,Zhengzhou,Henan,450000,China)

机构地区：[1]郑州人民医院妇产科,河南郑州450000

出　　处：《黑龙江医学》2023年第4期415-418,422,共5页Heilongjiang Medical Journal

摘　　要：目的:分析血清白细胞介素-10 (IL-10)、白细胞介素-17 (IL-17)与重度子痫前期(S-PE)患者胎膜早破(PROM)的关系并预测S-PE患者PROM风险价值。方法:回顾性分析2019年4月—2020年6月郑州人民医院发生PROM的49例S-PE患者资料,纳入发生PROM组。另收集同期未发生PROM的49例S-PE患者资料,纳入未发生PROM组。患者均于入院时检测血清IL-10、IL-17水平,且病例资料、实验室检查资料等均完整。收集并比较患者相关基线资料,重点分析入院时血清IL-10、IL-17水平与S-PE患者PROM的关系及预测S-PE患者PROM风险价值。结果:发生PROM组血清IL-10水平低于未发生PROM组,IL-17水平高于未发生PROM组,差异有统计学意义(U=5.407、6.217,P<0.05)。经logistic回归分析结果显示,血清IL-10、IL-17异常表达与S-PE患者发生PROM有关,IL-17升高可能是S-PE患者发生PROM的风险因子,差异有统计学意义(OR>1,P<0.05);IL-10升高可能是S-PE患者发生PROM的保护因子,差异有统计学意义(OR<1,P<0.05)。绘制ROC曲线发现,血清IL-10、IL-17单一及联合预测S-PE患者发生PROM风险的AUC均>0.80,均有一定预测价值;经一般线性双变量Spearman直线相关检验发现,S-PE患者血清IL-10与IL-17水平呈负相关(r<0,P<0.05)。结论:S-PE患者PROM可能与患者血清IL-10水平降低、IL-17水平升高有关,且血清IL-10、IL-17水平预测S-PE患者PROM有一定价值。Objective:To analyze the relationship between serum interleukin-10(IL-10) and interleukin-17(IL-17) and premature rupture of membranes(PROM) in patients with severe preeclampsia(S-PE) and to predict the value of PROM risk in S-PE patients.Methods:The data of 49 S-PE patients who had PROM in the hospital from April 2019-June 2020 were retrospectively analyzed and included in the group who had PROM. Data from another 49 S-PE patients who did not have PROM during the same period were collected and included in the group that did not have PROM. The patients were all tested for serum IL-10 and IL-17levels on admission, and the case data and laboratory test data were complete. Relevant baseline data of patients were collected and compared, focusing on the relationship between serum IL-10 and IL-17 levels at admission and PROM in S-PE patients and the value of predicting PROM risk in S-PE patients.Results:Serum IL-10 levels in the group with PROM were lower than those in the group without PROM, and IL-17 levels were higher than those in the group without PROM, with statistically significant differences(U=5.407, 6.217, P<0.05). The results of logistic regression analysis showed that abnormal expression of serum IL-10and IL-17 was associated with the development of PROM in patients with S-PE, and elevated IL-17 may be a risk factor for the development of PROM in patients with S-PE, with statistically significant differences(OR>1, P<0.05). Elevated IL-10 may be a protective factor for the development of PROM in patients with S-PE, with a statistically significant difference(OR<1, P<0.05).Plotting ROC curves revealed that the AUCs of serum IL-10 and IL-17 singly and in combination to predict the risk of PROM in patients with S-PE were >0.80, all of which had some predictive value. The general linear bivariate Spearman’s linear correlation test revealed that serum IL-10 was negatively correlated with IL-17 levels in S-PE patients(r<0, P<0.05).Conclusion:PROM in S-PE patients may be associated with lower serum IL-10 levels a

关 键 词：重度子痫前期 胎膜早破 白细胞介素-10 白细胞介素-17 

分 类 号：R657.4[医药卫生—外科学]