肺泡灌洗技术联合免疫球蛋白对重症支原体肺炎患儿肺功能、免疫功能以及炎症因子水平的影响  

Effect of Alveolar Lavage Technique Combined with Immunoglobulin on Pulmonary Function, Immune Function and Inflammatory Factor Levels in Children with Severe Mycoplasma Pneumonia

作　　者：王慧英[1] 汤昱 董利利[1] 王艳琼 WANG Hui-ying;TANG Yu;DONG Li-li(Respiratory Department,Children’s Hospital of Zhengzhou University,Children’s Hospital of Henan Province,Zhengzhou Children’s Hospital East,Zhengzhou,Henan,450000,China)

机构地区：[1]郑州大学附属儿童医院·河南省儿童医院·郑州儿童医院东区呼吸科,河南郑州450000

出　　处：《黑龙江医学》2023年第4期419-422,共4页Heilongjiang Medical Journal

基　　金：2018年度河南省医学科技攻关计划项目(2018020614)。

摘　　要：目的:分析肺泡灌洗技术联合免疫球蛋白对重症支原体肺炎患儿肺功能、免疫功能以及炎症因子水平的影响。方法:选择2019年7月—2020年7月样本医院收治的84例重症支原体肺炎患儿作为研究对象,根据随机数表法分为常规组和实验组,每组各42例。常规组予以免疫球蛋白治疗,实验组予以免疫球蛋白及肺泡灌洗治疗。对比每组患儿治疗干预前后炎症因子指标[白细胞介素―2 (IL-2)、白细胞介素―6 (IL-6)、白细胞介素―10 (IL-10)]、肺功能指标[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、呼气峰流速(PEF)]、免疫功能指标[免疫球蛋白G (IgG)、免疫球蛋白M(IgM)、免疫球蛋白A (IgA)]水平,并对比两组患儿的治疗有效率及各症状恢复时间。结果:实验组治疗总有效率高于常规组,差异有统计学意义(χ^(2)=5.571,P<0.05)。实验组退热时间、咳嗽消失时间、气促消失时间、肺部啰音消失时间、肺部X线阴影消失时间、住院时间均短于常规组,差异有统计学意义(t=6.684、12.062、4.398、10.317、6.114、4.398,P<0.05)。干预后,实验组FEV1、FVC及PEF水平均高于常规组,差异有统计学意义(t=9.042、7.849、7.172,P<0.05)。干预后,实验组IgA、IgM及IgG水平均低于常规组,差异有统计学意义(t=3.893、6.536、4.307,P<0.05)。干预后,实验组IL-10、IL-6、IL-2水平均低于常规组,差异有统计学意义(t=6.296、4.346、8.707,P<0.05)。结论:肺泡灌洗技术联合免疫球蛋白应用于重症支原体肺炎患儿中,能够提升患儿肺功能,改善其机体免疫功能,降低炎症因子水平。Objective:To analyze the effect of alveolar lavage technique combined with immunoglobulin on pulmonary function,immune function and inflammatory factor levels in children with severe mycoplasma pneumonia.Methods:84 cases of children with severe mycoplasma pneumonia admitted to the sample hospitals from July 2019 to July 2020 were selected as the study subjects and divided into conventional and experimental groups according to the random number table method, with 42 cases in each group. The conventional group was treated with immunoglobulin, and the experimental group was treated with immunoglobulin and alveolar lavage. The levels of inflammatory factors(interleukin-2 [IL-2], interleukin-6 [IL-6] and interleukin-10 [IL-10]), pulmonary function indicators(first second expiratory volume [FEV1], expiratory spirometry [FVC] and peak expiratory flow rate [PEF])and immune function indicators(immunoglobulin G [IgG], immunoglobulin M [IgM] and immunoglobulin A [IgA]) were compared before and after the treatment intervention in each group, and the treatment efficiency and recovery time of each symptom were compared between the two groups of children.Results:The total effective rate of the experimental group was higher than that of the conventional group, and the difference was statistically significant(χ^(2)=5.571, P<0.05). The time to fever reduction, time to disappearance of cough, time to disappearance of shortness of breath, time to disappearance of lung rales, time to disappearance of lung X-ray shadow, and hospitalization time were shorter in the experimental group than in the conventional group, and the differences were statistically significant(t=6.684, 12.062, 4.398, 10.317, 6.114, 4.398, P<0.05). After the intervention, FEV1, FVC and PEF levels were higher in the experimental group than in the conventional group, and the differences were statistically significant(t=9.042, 7.849, 7.172, P<0.05). After the intervention, the levels of IgA, IgM and IgG in the experimental group were lower than those in the conventio

关 键 词：免疫功能 肺功能 重症支原体肺炎 免疫球蛋白 肺泡灌洗 

分 类 号：R725.6[医药卫生—儿科]