Recent progress in Mg-based alloys as a novel bioabsorbable biomaterials for orthopedic applications  

作　　者：Fei Xing Shang Li Dongdi Yin Jichang Xie Pol Maria Rommens Zhou Xiang Ming Liu Ulrike Ritz 

机构地区：[1]Orthopedic Research Institute,Department of Orthopedics,West China Hospital,Sichuan University,No.37 Guoxue Lane,Chengdu,Sichuan 610041,China [2]Department of Plastic and Burn Surgery,West China Hospital,Sichuan University,No.37 Guoxue Lane,Chengdu,Sichuan 610041,China [3]Key Laboratory of Advanced Technologies of Materials,Ministry of Education,School of Materials Science and Engineering,Southwest Jiaotong University,Chengdu,Sichuan 610031,China [4]Laboratoire Roberval,FRE UTC-CNRS 2012,Sorbonne universités,Universitéde Technologie de Compiègne,Centre de recherche Royallieu,CS60319,Compiègne CEDEX 60203,France [5]Department of Orthopaedics and Traumatology,Biomatics Group,University Medical Center of the Johannes Gutenberg University,Langenbeckstr.1,Mainz 55131,Germany

出　　处：《Journal of Magnesium and Alloys》2022年第6期1428-1456,共29页镁合金学报（英文）

基　　金：supported by the National Natural Science Foundation of China(31870961,81501879);the Sino-German Center for Research Promotion(GZ1219);the International Cooperation Project of the Science and Technology Department of Sichuan Province(Grant No.2015HH0049,No.2017SZ0127,No.2020YFS0140);the National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University(Z2018A11)。

摘　　要：Traditional orthopedic metal implants,such as titanium(Ti),Ti alloys,and cobalt-chromium(Co-Cr)alloys,cannot be degraded in vivo.Fracture patients is must always suffer a second operation to remove the implants.Moreover,stress shielding,or stress protection occurs when traditional orthopedic metal implants are applied in fractures surgery.The mechanical shunt produced by traditional orthopedic metal implants can cause bone loss over time,resulting in decreased bone strength and delayed fracture healing.Biodegradable metals that‘biocorrode’are currently attracting significant interest in the orthopedics field due to their suitability as temporary implants.As one of the biodegradable metals,magnesium(Mg)and Mg alloys have gained interest in the field of medicine due to their low density,excellent biocompatibility,high bioresorbability,and proper mechanical properties.Additionally,Mg ions released from the metal implants can promote osteogenesis and angiogenesis during the degradation process in vivo,which is substantially better for orthopedic fixation than other bioinert metal materials.Therefore,this review focuses on the properties,fabrication,biological functions,and surface modification of Mg-based alloys as novel bioabsorbable biomaterials for orthopedic applications.

关 键 词：MAGNESIUM Mg alloys Biomedical implants Bone regeneration Surface modification 

分 类 号：R318.08[医药卫生—生物医学工程] TG146.22[医药卫生—基础医学]