不同剂量右美托咪定复合舒芬太尼用于小儿术后镇痛的效果对比分析  

Comparative Analysis of the Effect of Different Doses of Dexmedetomidine Combined with Sufentanil for Postoperative Analgesia in Children

作　　者：吴丽娟 郑建滨 黄玉景 吴少华 WU Lijuan;ZHENG Jianbin;HUANG Yujing;WU Shaohua(Department of Anesthesiology,Ningde Hospital,Ningde,Fujian Province,352000 China)

机构地区：[1]宁德市医院麻醉科,福建宁德352000

出　　处：《中外医疗》2022年第30期111-115,共5页China & Foreign Medical Treatment

摘　　要：目的 对比分析不同剂量右美托咪定复合舒芬太尼用于小儿术后镇痛的效果。方法 方便选取2019年1月—2020年12月于宁德市医院就诊的120例患儿,采取随机数表法将所有其均分为4组,每组30例,所有患儿均给予相同剂量舒芬太尼,不同组分别给予不同剂量的右美托咪定,S组(0μg/kg)、D1(低剂量组,1μg/kg)、D2(中剂量组,1.5μg/kg)、D3(高剂量组,2μg/kg),对比4组患儿术后镇痛效果。结果 与S组相比,其他3组患儿的术后Ramsay镇静评分均明显更高,差异有统计学意义(P<0.05),术后12 h评分最低,各组分别为(1.44±0.26)分、(1.98±0.35)分、(2.58±0.57)分、(2.36±0.35)分,差异有统计学意义(F=46.908,P<0.05)。在0~6、6~12、12~24 h3个时间段S组与其他3组患儿的PCA按压次数比较,差异有统计学意义(P<0.05),6~12 h内4组间差异最为显著,PCA按压次数分别为(1.44±0.58)、(1.21±0.42)、(0.42±0.28)、(0.68±0.33)次,差异有统计学意义(F=37.759,P<0.05);在24~48 h内4组患儿PCA按压次数对比,差异无统计学意义(P>0.05)。结论术后镇痛治疗时采取右美托咪定、舒芬太尼复合应用的效果明显优于单独使用舒芬太尼,并且不同剂量右美托咪定产生的效果也不相同,其中按照1.5μg/kg给予患儿中剂量的右美托咪定效果最佳。Objective To compare and analyze the effect of different doses of dexmedetomidine combined with sufentanil for postoperative analgesia in children.Methods 120 children from Ningde Hospital from January 2019 to December 2020 were conveniently selected, and divide them into 4 groups by random number table, with 30 cases in each group. All children were given the same dose of sufentanil, and different doses of dexmedetomidine were given to different groups. Group S(0 μg/kg), D1(low dose group, 1 μg/kg), D2(medium dose group, 1.5 μg/kg), D3(high dose group, 2 μg/kg), to compare the postoperative analgesic effects of the four groups.Results Compared with the Group S,the postoperative Ramsay sedation scores of the other three groups were significantly higher, and the difference was statistically significant(P<0.05). The score at 12 h after operation was the lowest, and the scores in each group were(1.44±0.26) points,(1.98±0.35) points,(2.58±0.57) points, and(2.36±0.35) points respectively, and the difference was statistically significant(F=46.908, P<0.05). The number of PCA compressions in group S and other three groups in 0-6 hours, 6-12 hours, 12-24 hours were compared, the difference was statistically significant(P<0.05). the difference among the 4 groups of patients was most significant during the period of 6-12 h, the number of PCA compressions was(1.44±0.58) times,(1.21±0.42) times,(0.42±0.28) times,(0.68±0.33) times, and the difference was statistically significant(F=37.759, P<0.05);there was no significant difference in the number of PCA compressions between the four groups during the 24-48 h period(P>0.05).Conclusion The effect of combined application of dexmedetomidine and sufentanil in postoperative analgesia is significantly better than that of sufentanil alone. And different doses of dexmedetomidine have different effects. Among them, the middle dose of dexmedetomidine given to children at 1.5 μg/kg has the best effect.

关 键 词：术后镇痛 舒芬太尼 右美托咪定 不同剂量 镇痛效果 

分 类 号：R614[医药卫生—麻醉学]