母血和脐血CD_(71)^(+)、Bcl-xL蛋白、sTREM-1及PCT水平与新生儿围产期感染的关联  

Association of maternal blood and cord blood CD_(71)^(+),Bcl-xL protein,sTREM-1 and PCT with perinatal infection in neonates

作　　者：贺宝军 杜红禹 单良 庞一心 王丹丹 HE Bao-jun;DU Hong-yu;SHAN Liang;PANG Yi-xin;WANG Dan-dan(The First Affiliated Hospital of Jinzhou Medical University,Jinzhou,Liaoning 121001,China)

机构地区：[1]锦州医科大学附属第一医院检验科,辽宁锦州121001

出　　处：《中华医院感染学杂志》2023年第1期120-124,共5页Chinese Journal of Nosocomiology

基　　金：辽宁省科学技术计划项目(2020-BS-246)。

摘　　要：目的 探究母血、脐血CD_(71)^(+)、Bcl-xL蛋白、可溶性髓样细胞触发受体-1(sTREM-1)及降钙素原(PCT)水平与新生儿围产期感染的关系。方法 选取2019年1月-2021年5月于锦州医科大学附属第一医院进行分娩并存在新生儿围产期感染的产妇62例为感染组,另采集同期正常妊娠分娩的产妇50名为对照组,收集产前母血及新生儿脐血,检测血液样本中CD_(71)^(+)、Bcl-xL、sTREM-1和PCT水平,采用受试者工作特征(ROC)曲线评估指标对新生儿围产期感染的鉴别价值。结果 与对照组相比,感染组母血、脐血中CD_(71)^(+)、sTREM-1和PCT升高,Bcl-xL降低(P<0.05);ROC曲线结果显示,母血CD_(71)^(+)和sTREM-1诊断新生儿感染的曲线下面积(AUC)均为0.807,脐血sTREM-1诊断新生儿感染的AUC为0.813;新生儿窒息、胎膜早破、羊水污染及妊娠期感染均是新生儿围产期感染的危险因素(P<0.05)。结论 CD_(71)^(+)、sTREM-1和PCT在孕晚期母血、脐血中水平升高,Bcl-xL水平降低,可作为预测新生儿围产期感染的有效指标。OBJECTIVE To explore the association of maternal blood and cord blood CD_(71)^(+), Bcl-xL protein, soluble triggering receptor expressed on myeloid cells(sTREM-1) and procalcitonin(PCT) with perinatal infection in neonates. METHODS A total of 62 puerperae who gave birth and had neonatal perinatal infection in the First Affiliated Hospital of Jinzhou Medical University from Jan 2019 to May 2021 were assigned as the infection group, meanwhile, 50 puerperae who had normal pregnancy and gave birth were chosen as the control group. The samples of maternal blood and cord blood of neonates were collected before the labor, the levels of CD_(71)^(+), Bcl-xL, sTREM-1 and PCT in the blood samples were detected, and the values of the indexes in differential diagnosis of perinatal infection were assessed by receiver operating characteristic(ROC) curves. RESULTS The levels of maternal blood and cord blood CD_(71)^(+), sTREM-1 and PCT of the infection group were higher than those of the control group, while the Bcl-xL level of the infection group was lower than that of the control group(P<0.05). The result of ROC curve analysis showed that the areas under curves(AUC) of both maternal blood CD_(71)^(+)and sTREM-1 were 0.807 in diagnosis of neonatal infection, and the AUC of cord blood sTREM-1 was 0.813 in diagnosis of neonatal infection. Neonatal asphyxia, premature rupture of fetal membranes, contamination of amniotic fluid and infection during pregnancy were the risk factors for the perinatal infection in the neonates(P<0.05). CONCLUSION The levels of CD_(71)^(+), sTREM-1 and PCT are elevated in maternal blood during the third trimester and cord blood, while the Bcl-xL level is reduced, the indexes are effective in prediction of perinatal infection in neonates.

关 键 词：CD_(71)^(+) BCL-XL蛋白 可溶性髓样细胞触发受体-1 降钙素原 新生儿围产期感染 

分 类 号：R722.13[医药卫生—儿科]