妊高症合并宫颈感染孕妇血浆ADMA、sFlt-1、PIGF水平与妊娠结局  

Relationship between plasma ADMA,sFlt-1,PIGF and pregnancy outcomes of pregnancy-induced hypertension women complicated with cervical infection

作　　者：荣赟 卜云涛 蒋静雯 雒碧云 高英芳[1] RONG Yun;BU Yun-tao;JIANG Jing-wen;LUO Bi-yun;GAO Ying-fang(Shijiazhuang Fourth Hospital,Shijiazhuang,Hebei 050000,China;不详)

机构地区：[1]石家庄市第四医院产科,河北石家庄050000 [2]中国人民解放军联勤保障部队第980医院心血管内科,河北石家庄050000

出　　处：《中华医院感染学杂志》2023年第2期261-265,共5页Chinese Journal of Nosocomiology

基　　金：河北省医学科学研究基金项目(20210271)。

摘　　要：目的探究妊娠期高血压疾病合并宫颈感染孕妇血浆非对称性二甲基精氨酸(ADMA)及可溶性血管内皮生长因子受体1(sFlt-1)和胎盘生长因子(PIGF)与妊娠结局的关系。方法选取2020年6月-2021年7月石家庄市第四医院建档并进行产检的80例单胎轻中度妊娠期高血压疾病合并宫颈感染孕妇为感染组,80例单胎轻中度妊娠期高血压疾病未合并宫颈感染孕妇为非感染组,80名正常单胎孕妇为对照组,采集宫颈感染孕妇宫颈分泌物进行病原菌培养,采用酶联免疫吸附法检测各组血浆ADMA、sFlt-1和PIGF水平,并记录不良妊娠结局。结果感染组孕妇共检出病原菌119株,以B型链球菌多见,占42.02%;感染组和非感染组ADMA、sFlt-1/PIGF水平高于对照组(P<0.05),且感染组ADMA、sFlt-1/PIGF水平高于非感染组(P<0.05);感染组新生儿窒息、围生儿死亡及剖宫产率高于非感染组和对照组,阴道分娩率低于非感染组和对照组(P<0.05);感染组妊娠结局正常孕妇血浆ADMA和sFlt-1/PIGF水平低于妊娠结局不良孕妇(P<0.05);血浆ADMA和sFlt-1/PIGF预测妊娠期高血压疾病合并宫颈感染孕妇妊娠结局的曲线下面积(AUC)分别为0.788、0.711。结论妊娠期高血压疾病合并宫颈感染致病菌以B型链球菌多见,且宫颈感染会恶化产妇妊娠结局,血浆ADMA和sFlt-1/PIGF对此类孕妇妊娠结局有一定预测价值。OBJECTIVE To explore the relationship between the plasma asymmetric dimethylarginine(ADMA),soluble fims-like tyrosine kinase receptor 1(sFlt-1),placental growth factor(PIGF)and the pregnancy outcomes of pregnancy-induced hypertension women complicated with cervical infection.METHODS From Jun 2020 to Jul 2021,a total of 80 singleton pregnancy and mild to moderate gestational hypertension women complicated with cervical infection who received prenatal checkups in Shijiazhuang Fourth Hospital were assigned as the infection group,meanwhile,80 singleton pregnancy and mild to moderate gestational hypertension women without cervical infection were assigned as the no infection group,and 80 normal singleton pregnancy women were chosen as the control group.The cervical secretions specimens were collected from the pregnant women with cervical infection so as to carry out the culture of pathogens.The levels of plasma ADMA,sFlt-1 and PIGF were detected by enzyme-linked immunosorbent assay,and the adverse pregnancy outcomes were recorded.RESULTS Totally 119 strains of pathogens were isolated from the infection group,among which group B Streptococcus was common,accounting for 42.02%.The levels of ADMA and sFlt-1/PIGF of the infection group and the no infection group were higher than those of the control group(P<0.05),and the levels of ADMA and sFlt-1/PIGF of the infection group were higher than those of the no infection group(P<0.05).The incidence of neonatal asphyxia,perinatal death and rate of cesarean section were higher in the infection group than in the no infection group and the control group,while the rate of vaginal delivery of the infection group was lower than that of the no infection group and the control group(P<0.05).In the infection group,the levels of plasma ADMA and sFlt-1/PIGF of the pregnant women with normal pregnancy outcomes were lower than those of the pregnant women with adverse pregnancy outcomes(P<0.05).Areas under curves(AUCs)of the plasma ADMA and sFlt-1/PIGF were respectively 0.788 and 0.711 in predi

关 键 词：妊娠期高血压疾病 宫颈感染 致病菌谱 非对称性二甲基精氨酸 血管内皮生长因子受体1 胎盘生长因子 

分 类 号：R711.32[医药卫生—妇产科学]