四川省凉山地区高风险人乳头瘤病毒亚型分布研究  

Study of the Distribution of High-Risk Human Papilloma Virus Subtypes in Liangshan Region,Sichuan Province

作　　者：陈华秋 陈兴友 王光明 Chen Huaqiu;Chen Xingyou;Wang Guangming(Department of Laboratory,Xichang People's Hospital,Xichang,Sichuan 615000,China;Department of Pathology,Xichang People's Hospital,Xichang,Sichuan 615000,China;Gene Testing Center,The First Affiliated Hospital of Dali University,Dali,Yunnan 671000,China)

机构地区：[1]西昌市人民医院检验科,四川西昌615000 [2]西昌市人民医院病理科,四川西昌615000 [3]大理大学第一附属医院基因检测中心,云南大理671000

出　　处：《大理大学学报》2023年第2期51-55,共5页Journal of Dali University

基　　金：凉山彝族自治州科技计划重点研发项目(21ZDYF0173)。

摘　　要：目的:了解四川省凉山地区女性高风险人乳头瘤病毒(HR-HPV)的感染特点,为该地区HPV疫苗开发和应用提供数据支持。方法:应用PCR-荧光探针法对2018年11月14日至2020年12月30日在西昌市人民医院体检中心和妇产科门诊就诊的7445例女性行HR-HPV检测,并对检测结果进行统计分析。结果:7445例样本中HR-HPV阳性1027例,阳性率为13.79%,15种HR-HPV亚型均有检出;其中单一型感染者818例(占79.65%),多重感染者209例(占20.35%);HR-HPV感染阳性率排名前三的亚型分别为HPV 52型、16型和53型;在各个年龄段中,年龄≥61岁的受检者阳性率最高(占22.39%),其次为21~30岁的受检者(占15.86%)。结论:四川省凉山地区HR-HPV亚型感染分布具有一定的区域性,61岁以上者阳性率最高,因此应加强适龄人群HR-HPV筛查的宣传力度。Objective:To understand the characteristics of high-risk human papillomavirus(HR-HPV)infection among women in Liangshan Region,Sichuan Province,and to provide data support for the development and application of HPV vaccine in this area.Methods:The PCR fluorescence probe method was used to detect HR-HPV in 7445 women who visited the physical examination center of Xichang People’s Hospital and the outpatient department of obstetrics and gynecology from November 14,2018 to December30,2020,and the detection results were statistically analyzed.Results:Among the 7445 samples,1027 were HR-HPV positive,with a positive rate of 13.79%,and all 15 HR-HPV subtypes were detected.Among them,818 cases(79.65%)were single infection,and 209 cases(20.35%)were multiple infection.The top three subtypes of HR-HPV infection were HPV 52,16 and 53.In all age groups,the positive rate of subjects aged≥61 years was the highest(22.39%),followed by subjects aged 21-30 years(15.86%).Conclusion:The distribution of HR-HPV subtype infection in Liangshan Region,Sichuan Province has certain regional characteristics,and the positive rate is the highest among people over 61 years old.Therefore,it is necessary to strengthen the publicity of HR-HPV screening among the suitable age population.

关 键 词：高风险人乳头瘤病毒 PCR-荧光探针法 宫颈癌 

分 类 号：R446.61[医药卫生—诊断学]