Prevention,diagnostic evaluation,management and prognostic implications of liver disease in critically ill patients with COVID-19  

作　　者：Asimina Valsamaki Maria Xanthoudaki Katerina G Oikonomou Panagiotis J Vlachostergios AntoniosPapadogoulas Periklis Katsiafylloudis Ioanna Voulgaridi Apostolia-Lemonia Skoura Apostolos Komnos Panagiotis Papamichalis 

机构地区：[1]Intensive Care Unit,General Hospital of Larissa,Larissa 41221,Greece [2]Division of Hematology and Medical Oncology,Department of Medicine,Weill Cornell Medicine,New York,NY 10065,United States [3]Department of Microbiology,General Hospital of Larissa,Larissa 41221,Greece [4]Transfusion Medicine Department,University Hospital of Larissa,Larissa 41110,Greece

出　　处：《World Journal of Clinical Cases》2023年第3期514-527,共14页世界临床病例杂志

摘　　要：Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2,broke out in December 2019 in Wuhan city of China and spread rapidly worldwide.Therefore,by March 2020,the World Health Organization declared the disease a global pandemic.Apart from the respiratory system,various other organs of the human body are also seriously affected by the virus.Liver injury in patients with a severe form of COVID-19 is estimated to be 14.8%-53.0%.Elevated levels of total bilirubin,aspartate aminotransferase and alanine aminotransferase and low levels of serum albumin and prealbumin are the main laboratory findings.Patients with pre-existing chronic liver disease and cirrhosis are much more prone to develop severe liver injury.This literature review presented the recent scientific findings regarding the pathophysiological mechanisms responsible for liver injury in critically ill patients with COVID-19,the various interactions between drugs used to treat the disease and the function of the liver and the specific tests providing the possibility of early diagnosis of severe liver injury in these patients.Moreover,it highlighted the burden that COVID-19 put on health systems worldwide and its effect on transplant programs and the care provided to critically ill patients in general and particularly to those with chronic liver disease.

关 键 词：Coronavirus disease 2019 Severe acute respiratory syndrome coronavirus 2 Liver disease Intensive care unit Liver unit PREALBUMIN 

分 类 号：R563.1[医药卫生—呼吸系统]