Metagenomic next-generation sequencing for pleural effusions induced by viral pleurisy:A case report  

作　　者：Xue-Ping Liu Chen-Xue Mao Guan-Song Wang Ming-Zhou Zhang 

机构地区：[1]Institute of Respiratory Disease,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China [2]Department of Laboratory Diagnosis,Chongqing KingMed Center for Clinical Laboratory Co.,Ltd,Chongqing 400050,China

出　　处：《World Journal of Clinical Cases》2023年第4期844-851,共8页世界临床病例杂志

摘　　要：BACKGROUND Viral pleurisy is a viral infected disease with exudative pleural effusions.It is one of the causes for pleural effusions.Because of the difficult etiology diagnosis,clinically pleural effusions tend to be misdiagnosed as tuberculous pleurisy or idiopathic pleural effusion.Here,we report a case of pleural effusion secondary to viral pleurisy which is driven by infection with epstein-barr virus.Viral infection was identified by metagenomic next-generation sequencing(mNGS).CASE SUMMARY A 40-year-old male with a history of dermatomyositis,rheumatoid arthritis,and secondary interstitial pneumonia was administered with long-term oral prednisone.He presented with fever and chest pain after exposure to cold,accompanied by generalized sore and weakness,night sweat,occasional cough,and few sputums.The computed tomography scan showed bilateral pleural effusions and atelectasis of the partial right lower lobe was revealed.The pleural fluids were found to be yellow and slightly turbid after pleural catheterization.Thoracoscopy showed fibrous adhesion and auto-pleurodesis.Combining the results in pleural fluid analysis and mNGS,the patient was diagnosed as viral pleuritis.After receiving Aciclovir,the symptoms and signs of the patient were relieved.CONCLUSION Viral infection should be considered in cases of idiopathic pleural effusion unexplained by routine examination.mNGS is helpful for diagnosis.

关 键 词：Pleural effusions Viral pleurisy Metagenomic next-generation sequencing Epstein-barr virus INFECTION Case report 

分 类 号：R99[医药卫生—毒理学]