Contributions of the receptor for advanced glycation end products axis activation in gastric cancer  

作　　者：Armando Rojas Cristian Lindner Iván Schneider Ileana González Miguel Angel Morales 

机构地区：[1]Biomedical Research Laboratories,Medicine Faculty,Catholic University of Maule,Talca 34600000,Chile [2]Medicine Faculty,Catholic University of Maule,Talca 34600000,Chile [3]Molecular and Clinical Pharmacology Program,Institute of Biomedical Sciences,University of Chile,Santiago 8320000,Chile

出　　处：《World Journal of Gastroenterology》2023年第6期997-1010,共14页世界胃肠病学杂志（英文版）

摘　　要：Compelling shreds of evidence derived from both clinical and experimental research have demonstrated the crucial contribution of receptor for advanced glycation end products(RAGE)axis activation in the development of neoplasms,including gastric cancer(GC).This new actor in tumor biology plays an important role in the onset of a crucial and long-lasting inflammatory milieu,not only by supporting phenotypic changes favoring growth and dissemination of tumor cells,but also by functioning as a pattern-recognition receptor in the inflammatory response to Helicobacter pylori infection.In the present review,we aim to highlight how the overexpression and activation of the RAGE axis contributes to the proliferation and survival of GC cells as and their acquisition of more invasive phenotypes that promote dissemination and metastasis.Finally,the contribution of some single nucleotide polymorphisms in the RAGE gene as susceptibility or poor prognosis factors is also discussed.

关 键 词：Gastric cancer Advanced glycation end-products Receptor of advanced glycation end-products ALARMINS Helicobacter pylori Chronic inflammation 

分 类 号：R735.2[医药卫生—肿瘤]