Functional constipation in children:What physicians should know  

作　　者：Duc Long Tran Palittiya Sintusek 

机构地区：[1]Thailand and Department of Pediatrics,Faculty of Medicine,Chulalongkorn University,Bangkok 10330,Bangkok,Thailand [2]Faculty of Medicine,Can Tho University of Medicine and Pharmacy,Can Tho City 9000,Viet Nam [3]Thai Pediatric Gastroenterology,Hepatology and Immunology Research Unit,Division of Gastroenterology,Department of Pediatrics,King Chulalongkorn Memorial Hospital and Thai Red Cross,Faculty of Medicine,Chulalongkorn University,Bangkok 10330,Thailand

出　　处：《World Journal of Gastroenterology》2023年第8期1261-1288,共28页世界胃肠病学杂志（英文版）

基　　金：Thailand and Thailand Science Research and Innovation Fund Chulalongkorn University,No.HEA663000047.

摘　　要：Functional constipation(FC)is considered the most common functional gastrointestinal disorder in children with a pooled global prevalence of 14.4%(95%confidence interval:11.2-17.6)when diagnosed based on the Rome IV criteria.Its pathophysiological mechanisms are thought be multifactorial and complicated,resulting in difficult management.Currently,the most effective medication,when used in parallel with toilet training,is osmotic laxatives.Children’s adherence to medication and parental concern regarding long-term laxative use are the main contributors to treatment failure.Recently,novel therapies with a high safety profile have been developed,such as probiotics,synbiotics,serotonin 5-hydroxytryptamine 4 receptor agonists,chloride channel activators,and herbal and transitional medicines;nonetheless,well-designed research to support the use of these therapies is needed.This review aims to focus on multiple aspects of FC in children,including global prevalence,pathogenesis,diagnostic criteria,tools,as well as conventional and novel treatment options,such as non-pharmacological management,including adequate fiber and fluid intake,physiotherapy,or neuromodulators.We also report that in very difficult cases,surgical intervention may be required.

关 键 词：CONSTIPATION CHILDREN LAXATIVE Treatment Toilet training HERBAL 

分 类 号：R725.7[医药卫生—儿科]