Molecular mechanisms implicated in SARS-CoV-2 liver tropism  

作　　者：Jorge Quarleri M.Victoria Delpino 

机构地区：[1]Institute for Biomedical Research on Retroviruses and AIDS,Faculty of Medical Sciences,National Scientific and Technical Research Council-University of Buenos Aires,Buenos Aires 1121,Argentina

出　　处：《World Journal of Gastroenterology》2022年第48期6875-6887,共13页世界胃肠病学杂志（英文版）

摘　　要：The coronavirus disease 2019(COVID-19)pandemic is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Hepatic involvement is common in SARS-CoV-2-infected individuals.It is currently accepted that the direct and indirect hepatic effects of SARS-CoV-2 infection play a significant role in COVID-19.In individuals with pre-existing infectious and non-infectious liver disease,who are at a remarkably higher risk of developing severe COVID-19 and death,this pathology is most medically relevant.This review emphasizes the current pathways regarded as contributing to the gastrointestinal and hepatic ailments linked to COVID-19-infected patients due to an imbalanced interaction among the liver,systemic inflammation,disrupted coagulation,and the lung.

关 键 词：SARS-CoV-2 Viral hepatitis Non-infectious liver disease Hyperinflammation Coronavirus disease 2019 

分 类 号：R373[医药卫生—病原生物学]