COVID-19 and hepatic injury: cellular and molecular mechanisms in diverse liver cells  

作　　者：Fares E M Ali Mostafa K Abd El-Aziz Mahmoud M Ali Osama M Ghogar Adel G Bakr 

机构地区：[1]Department of Pharmacology and Toxicology,Faculty of Pharmacy,Al-Azhar University,Assiut 71524,Egypt [2]Department of Pharmacology, Al-Azhar University,Assiut 71524,Egypt [3]Department of Biochemistry Faculty of Pharmacy, Badr University in Assiut,Egypt

出　　处：《World Journal of Gastroenterology》2023年第3期425-449,共25页世界胃肠病学杂志（英文版）

摘　　要：The coronavirus disease 2019(COVID-19)represents a global health and economic challenge.Hepatic injuries have been approved to be associated with severe acute respiratory syndrome coronavirus(SARS-CoV-2)infection.The viral tropism pattern of SARS-CoV-2 can induce hepatic injuries either by itself or by worsening the conditions of patients with hepatic diseases.Besides,other factors have been reported to play a crucial role in the pathological forms of hepatic injuries induced by SARS-CoV-2,including cytokine storm,hypoxia,endothelial cells,and even some treatments for COVID-19.On the other hand,several groups of people could be at risk of hepatic COVID-19 complications,such as pregnant women and neonates.The present review outlines and discusses the interplay between SARS-CoV-2 infection and hepatic injury,hepatic illness comorbidity,and risk factors.Besides,it is focused on the vaccination process and the role of developed vac-cines in preventing hepatic injuries due to SARS-CoV-2 infection.

关 键 词：COVID-19 Hepatic injury Viral tropism COVID-19 comorbidity VACCINATION 

分 类 号：R563.1[医药卫生—呼吸系统] R575[医药卫生—内科学]