Two methods of lung biopsy for histological confirmation of acute fibrinous and organizing pneumonia:A case report  

作　　者：Wen-Juan Liu Shuang Zhou Yan-Xia Li 

机构地区：[1]Department of Respiratory and Critical Care Medicine,Institute of Respiratory Diseases,The First Affiliated Hospital of Dalian Medical University,Dalian 116011,Liaoning Province,China [2]Department of Internal Medicine,Dalian Medical University,Dalian 116044,Liaoning Province,China

出　　处：《World Journal of Clinical Cases》2022年第36期13381-13387,共7页世界临床病例杂志

基　　金：Supported by Natural Science Foundation of Liaoning Province,No.2021-MS-287。

摘　　要：BACKGROUND Acute fibrinous and organizing pneumonia(AFOP)is a rare,noninfective lung disease,histologically characterized by a patchy distribution of intra-alveolar fibrin“balls”and organizing pneumonia.The clinical manifestations of AFOP are nonspecific.Diagnosis depends on pathology.Surgical lung biopsy is optimal for tissue sampling to diagnose AFOP.However,many patients have no tolerance to the operation,including mentally and physically.There is still no standard therapy for AFOP and the methods remain controversial.Therefore,further clinical attention and discussion are warranted.CASE SUMMARY A 53-year-old woman presented with fever,cough and dyspnea for 15 d.Antiinfective therapy was ineffective.Chest computed tomography showed bilateral patchy consolidation,especially in the lower lobes.We performed both ultrasound-guided transbronchial lung biopsy and ultrasound-guided percutaneous fine needle puncture at different lung lesion locations.Both samples supported the diagnosis of AFOP.The patient had a good clinical course after treatment with methylprednisolone,and no side effects of steroids.CONCLUSION Percutaneous needle biopsy combined with transbronchial lung biopsies may be a good choice in the absence of surgical biopsy.Methylprednisolone alone is effective in the treatment of idiopathic AFOP.

关 键 词：Acute fibrinous and organizing pneumonia Fibrin balls Percutaneous needle biopsy Transbronchial lung biopsies METHYLPREDNISOLONE Case report 

分 类 号：R563.1[医药卫生—呼吸系统]