功能纳米材料应用于电化学新冠病毒生物传感器的研究进展  

Functional Nanomaterials for Electrochemical SRAS-CoV-2 Biosensors:a Review

作　　者：刘瑶 尤勋海 赵冰 罗晓莹[4] 陈星 LIU Yao;YOU Xunhai;ZHAO Bing;LUO Xiaoying;CHEN Xing(Institute of Industry and Equipment Technology,Hefei University of Technology,Hefei 230009,China;School of Resources and Environmental Engineering,Hefei University of Technology,Hefei 230009,China;School of Materials Science and Engineering,Hefei University of Technology,Hefei 230009,China;State Key Laboratory of Oncogenes and Related Genes,Shanghai Cancer Institute,Renji Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 200032,China)

机构地区：[1]合肥工业大学工业与装备技术研究院,合肥230009 [2]合肥工业大学资源与环境工程学院,合肥230009 [3]合肥工业大学材料科学与工程学院,合肥230009 [4]上海交通大学医学院附属仁济医院上海市肿瘤研究所癌基因与相关基因国家重点实验室,上海200032

出　　处：《无机材料学报》2023年第1期32-42,共11页Journal of Inorganic Materials

基　　金：国家重点研发计划(SQ2021YFE011305)。

摘　　要：新冠疫情暴发对全球公共卫生构成了巨大威胁,病毒的快速、准确诊断对新冠疫情防控具有至关重要的作用。近年来,以纳米材料为基础的电化学传感技术在快速、高灵敏度/高特异性分子诊断方面显示出巨大的潜力。本文简要介绍了新型冠状病毒(SARS-CoV-2)的结构特征及常规检测方法,总结了电化学生物检测相关传感特点和机制。在此基础上,详细评述了金纳米材料、氧化物纳米材料、碳基纳米材料等为基础的电化学传感器用于快速、准确检测新冠病毒的研究进展。最后,展望了基于电化学传感技术在未来生物分子诊断中的应用。The pandemic outbreak of COVID-19 has posed a threat to public health globally,and rapid and accurate identification of the viruses is crucial for controlling COVID-19.In recent years,nanomaterial-based electrochemical sensing techniques hold immense potential for molecular diagnosis with high sensitivity and specificity.In this review,we briefly introduced the structural characteristics and routine detection methods of SARS-CoV-2,then summarized the associated properties and mechanisms of the electrochemical biosensing methods.On the above basis,the research progress of electrochemical biosensors based on gold nanomaterials,oxide nanomaterials,carbon-based nanomaterials and other nanomaterials for rapid and accurate detection of virus were reviewed.Finally,the future applications of nanomaterial-based biosensors for biomolecular diagnostics were pointed out.

关 键 词：SARS-CoV-2 电化学生物传感器 纳米材料 快速诊断 综述 

分 类 号：TQ174[化学工程—陶瓷工业]