丙型肝炎患者健康相关生命质量现状及相关因素分析  

Health-related quality of life and associated factors in hepatitis C patients

作　　者：虞接军 徐朋 杨丹丹[2] 张琬悦[3] 刘鹏程 柴菲菲 龚丽华 袁庆 刘中夫[1] 李健[1] YU Jiejun;XU Peng;YANG Dandan;ZHANG Wanyue;LIU Pengcheng;CHAI Feifei;GONG Lihua;YUAN Qing;LIU Zhongfu;LI Jian(National Center for STD/AIDS Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China;Center for Disease Control and Prevention,Jiangsu Province,Nanjing 210009;Center for Disease Control and Prevention,Yunnan Province,Kunming 650034;Center for Disease Control and Prevention,Xuzhou City,Xuzhou 221006;Center for Disease Control and Prevention,Wenshan Zhuang and Miao Autonomous Prefecture,Wenshan,663099)

机构地区：[1]中国疾病预防控制中心性病艾滋病预防控制中心,北京102206 [2]江苏省疾病预防控制中心,南京210009 [3]云南省疾病预防控制中心,昆明650034 [4]徐州市疾病预防控制中心,江苏徐州221006 [5]文山壮族苗族自治州疾病预防控制中心,云南文山663099

出　　处：《中国艾滋病性病》2023年第1期33-38,共6页Chinese Journal of Aids & STD

摘　　要：目的了解丙型肝炎(简称丙肝)患者健康相关生命质量现状并分析其相关因素,为提高丙肝患者健康相关生命质量及制定相关干预策略和措施提供依据。方法2022年7-9月,在云南省文山州和江苏省徐州市采用SF-36量表调查丙肝患者的健康相关生命质量状况。描述调查对象的社会人口学特征、病程、有无肝脏不适感和治疗等情况,采用t检验或方差分析进行组间比较,采用多元线性回归模型分析调查对象健康相关生命质量的相关因素。结果共招募486名研究对象,获得有效问卷483份(99.38%)。统计分析结果显示,在SF-36量表的8个维度中,生理功能维度得分最高,总体健康维度得分最低,生理健康综合得分为(71.90±22.77)分,心理健康综合得分为(72.83±20.00)分,治疗的患者健康相关生命质量略高于未治疗的患者。多元线性回归模型分析结果显示,在生理健康方面,<50岁(β=9.484,95%CI:5.831~13.137)、家庭人均月收入在1000~3000元者(β=8.797,95%CI:4.828~12.765)、3001~5000元者(β=14.817,95%CI:9.069~20.566)、>5000元者(β=9.592,95%CI:0.275~18.909)、未患其他疾病者(β=11.541,95%CI:7.922~15.159)、无肝脏不适者(β=12.055,95%CI:7.827~16.284)的得分更高;在心理健康方面,<50岁者(β=4.710,95%CI:1.165~8.255)、家庭人均月收入在3001~5000元者(β=10.923,95%CI:5.474~16.373)和>5000元者(β=8.695,95%CI:0.038~17.353)、未患其他疾病者(β=9.052,95%CI:5.678~12.426)、无肝脏不适者(β=9.482,95%CI:5.718~13.247)的得分更高,农民或民工(β=-7.795,95%CI:-8.881~-0.492)得分更低。结论抗病毒治疗能提高丙肝患者的健康相关生命质量,但不明显。需制定相关干预策略和措施降低丙肝对人体的危害,提高该人群的健康状况,尤其关注年龄大、收入低、患有其他疾病和出现肝脏不适感的患者。Objective To understand the current situation of the health-related quality of life of hepatitis C patients and its related factors to provide a basis for improving the health-related quality of life of hepatitis C patients and formulating related intervention strategies and measures.Methods From July to September 2022,the SF-36 scale was used to investigate the health-related quality of life status of patients with hepatitis C in Wenshan Prefecture,Yunnan Province and Xuzhou City,Jiangsu Province.Sociodemographic characteristics,disease duration,presence of liver discomfort,and treatment of the survey subjects were described.T-test or ANOVA was used to compare between groups and multiple linear regression models were used to analyze the factors associated with the health-related quality of life of the survey subjects.Results 486 study subjects were recruited,with 483 valid questionnaires(99.38%).Among the eight dimensions of the SF-36 scale,the highest score was obtained for the physical function dimension and the lowest for the general health dimension,with a composite score of(71.90±22.77)for physical health and(72.83±20.00)for mental health.Treated patients had a slightly higher health-related quality of life than the untreated patients.The results of the multiple linear regression model analysis showed that in terms of physical health,those<50 years old(β=9.484,95%CI:5.831-13.137),monthly per capita household income of 1000-3000 RMB yuan(β=8.797,95%CI:4.828-12.765),3001-5000 RMB yuan(β=14.817,95%CI:9.069-20.566),>5000 RMB yuan(β=9.592,95%CI:0.275-18.909),without other diseases(β=11.541,95%CI:7.922-15.159)and without liver discomfort(β=12.055,95%CI:7.827-16.284)had higher scores.In terms of mental health,those<50 years old(β=4.710,95%CI:1.165-8.255),monthly per capita household income of 3001-5000 RMB yuan(β=10.923,95%CI:5.474-16.373)and those with>5000 RMB yuan(β=8.695,95%CI:0.038-17.353),without other diseases(β=9.052,95%CI:5.678-12.426),without liver discomfort(β=9.482,95%CI:5.718-13.247)had h

关 键 词：丙型肝炎患者 SF-36问卷 健康相关生命质量 

分 类 号：R512.91[医药卫生—内科学]