双硫仑在炎症相关疾病中作用的研究进展  

Research progress of disulfiram in inflammation-related diseases

作　　者：黄秋洋 陈小中 戴晨 余秀燕 沈燕 林治华 HUANG Qiuyang;CHEN Xiaozhong;DAI Chen;YU Xiuyan;SHEN Yan;LIN Zhihua(School of Pharmacy and Bioengineering,Chongqing University of Technology,Chongqing,400054 P.R.China;Chongqing Key Laboratory of Targeted Drug Screening and Activity Evaluation,Chongqing Key Laboratoty of Medicinal Chemistry and Molecular Pharmacology,Chongqing University of Technology,Chongqing,400054 P.R.China)

机构地区：[1]重庆理工大学药学与生物工程学院,重庆400054 [2]重庆理工大学、药物化学与分子药理学重点实验室、靶向药物筛选与活性评价重点实验室,重庆400054

出　　处：《华西药学杂志》2023年第1期117-122,共6页West China Journal of Pharmaceutical Sciences

基　　金：重庆市教委科学技术研究项目(KJQN202101150);国家自然科学基金资助项目(批准号:82100684);重庆理工大学研究生创新基金校级联合资助项目(gzlcx20223337)。

摘　　要：双硫仑作为FDA批准的戒酒药在临床上被广泛使用。双硫仑主要通过抑制NLRP3炎症小体活化、Gasdermin D蛋白膜孔形成、中性粒细胞胞外捕网的形成及释放、抑制核转录因子κB激活等机制,抑制炎症反应并改善炎性相关疾病。此外,双硫仑与其他药物联合使用可提升其抗炎作用。现对双硫仑抗炎作用的分子机制及其在炎性疾病中的作用进行综述,以期为双硫仑作为抗炎药物的应用提供参考。Disulfiram approved by FDA has a long history of being used for alcohol abuse.This agent inhibits inflammatory response and improves inflammation-related diseases mainly by inhibiting the activation of NLRP3 inflammasome, the formation of Gasdermin D membrane pores, the formation and release of Netrophic extracelluar traps, and activation of NF-κB.In addition, disulfiram combined with other drugs can enhance its anti-inflammatory effect.This paper reviews briefly the major findings concerning the molecular mechanism of disulfiram in connection with inflammatory diseases, hoping to provide the basis for the application and research of disulfiram as an anti-inflammatory drug.

关 键 词：双硫仑 炎症反应 NLRP3炎症小体 Gasdermin D蛋白 中性粒细胞胞外捕网 核转录因子ΚB 抗炎作用 分子机制 

分 类 号：R96[医药卫生—药理学]