半夏饮子加减联合热敏灸治疗中虚气逆型胃食管反流病的临床观察  

Clinical Observation of Modified Pinelliae Rhizoma Decoction Combined with Thermal Sensitive Moxibustion for the Treatment of Gastroesophageal Reflux Disease with Deficiency of Middle Energizer and Reversed Flow of Qi Syndrome

作　　者：陈小婉 幸思忠(指导) CHEN Xiao-Wan;XING Si-Zhong(The Seventh Clinical Medical School of Guangzhou University of Chinese Medicine,Guangzhou 518133 Guangdong,China)

机构地区：[1]广州中医药大学第七临床医学院,广东深圳518133

出　　处：《广州中医药大学学报》2023年第1期69-74,共6页Journal of Guangzhou University of Traditional Chinese Medicine

摘　　要：【目的】观察半夏饮子加减联合热敏灸治疗中虚气逆型胃食管反流病(GERD)的临床疗效。【方法】将80例中虚气逆型GERD患者随机分为治疗组和对照组,每组各40例。治疗组给予半夏饮子加减联合热敏灸治疗,对照组给予口服奥美拉唑肠溶胶囊合枸橼酸莫沙必利片治疗,疗程均为8周。观察2组患者治疗前后反流性疾病问卷(RDQ)积分、中医证候积分、24 h食管下段pH<4总时间的变化情况,并评价2组患者的临床疗效。【结果】(1)研究过程中,治疗组中止1例,剔除2例,最终纳入37例;对照组中止1例,剔除1例,最终纳入38例。(2)治疗8周后,治疗组的总有效率为91.89%(34/37),对照组为81.58%(31/38);组间比较,治疗组的总有效率(Fisher精确检验)和总体疗效(秩和检验)均优于对照组,差异均有统计学意义(P<0.05)。(3)治疗后,2组患者的RDQ积分、中医证候积分、24 h食管下段pH<4总时间均较治疗前明显改善(P<0.05),且治疗组的改善幅度均明显优于对照组,差异均有统计学意义(P<0.05)。【结论】半夏饮子加减联合热敏灸治疗中虚气逆型GERD患者疗效确切,其疗效优于常规西药治疗。Objective To observe the clinical efficacy of modified Pinelliae Rhizoma Decoction combined with thermal sensitive moxibustion for the treatment of gastroesophageal reflux disease(GERD)with deficiency of middle energizer and reversed flow of qi syndrome.Methods Eighty cases of GERD with deficiency of middle energizer and reversed flow of qi syndrome were randomly divided into the treatment group and the control group,with 40 cases in each group.The treatment group was given modified Pinelliae Rhizoma Decoction orally combined with thermal sensitive moxibustion,while the control group was given oral use of Omeprazole Enteric-coated Capsules combined with Mosapride Citrate Tablets.The treatment for both groups lasted 8 weeks.The changes in the Reflux Disease Questionnaire(RDQ)scores,traditional Chinese medicine(TCM)syndrome scores and the total time of 24-hour pH being less than 4 in the lower esophageal in the two groups before and after treatment were observed,and then the clinical efficacy of the patients in the two groups was also evaluated.Results(1)During the trial,one case was discontinued and two cases were excluded from the treatment group,and a total of 37 cases were eventually included;one case was discontinued and one case was excluded from the control group,and a total of 38 cases were eventually included.(2)After 8 weeks of treatment,the overall effective rate in the treatment group was 91.89%(34/37)and that in the control group was 81.58%(31/38).The intergroup comparison showed that the overall effective rate tested by Fisher’s exact test and the overall efficacy tested by rank sum test in the treatment group were superior to those in the control group,and the differences were statistically significant(P<0.05).(3)After treatment,the RDQ scores,TCM syndrome scores and the total time of 24-hour pH being less than 4 in the lower esophageal in both groups were significantly improved compared with those before treatment(P<0.05),and the improvement in the treatment group was significantly superior to tha

关 键 词：中虚气逆 胃食管反流 半夏饮子 热敏灸 反流性疾病问卷(RDQ)积分 中医证候积分 

分 类 号：R259.71[医药卫生—中西医结合]