鹧鸪茶对高脂血症痰浊阻遏证患者的降脂效果及肠道菌群的影响  

Impact of Zhegu Tea on the Hypolipidemic Effect and Intestinal Flora in Patients with Hyperlipidemia of Blockage of Turbid Phlegm Syndrome

作　　者：卓书江 张明[1] 林道斌 ZHUO Shu-Jiang;ZHANGMing;LIN Dao-Bin(Dept.of Cardiovascular Medicine,Hainan Traditional Chinese Medicine Hospital,Haikou 570203 Hainan,China)

机构地区：[1]海南省中医院心血管内科,海南海口570203

出　　处：《广州中医药大学学报》2023年第2期300-308,共9页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：海南省自然科学基金高层次人才项目(编号:2019RC383);海南省卫生计生行业科研项目(编号:20A200153)。

摘　　要：【目的】探讨鹧鸪茶对高脂血症痰浊阻遏证患者的降脂效果及肠道菌群的影响。【方法】将40例高脂血症痰浊阻遏证患者随机分为试验组和对照组,每组各20例。所有患者均按照指南推荐的运动方法进行降脂治疗,试验组在此基础上加用鹧鸪茶治疗,治疗周期为8周。观察2组患者干预前后的中医证候积分、体质量指数(BMI)和血脂指标的变化情况,评价2组患者的中医证候疗效。此外,在治疗结束后采集2组患者和10例健康人的新鲜粪便检测肠道菌群。【结果】(1)干预8周后,试验组的总有效率为95.0%(19/20),对照组为15.0%(3/20),组间比较,试验组的中医证候疗效明显优于对照组(P<0.01)。(2)治疗后,试验组的形体肥胖、头重如裹、呕吐痰涎、口淡及食少等证候积分均较治疗前改善(P<0.05或P<0.01),而对照组仅形体肥胖及口淡等证候积分较治疗前改善(P<0.05);组间比较,试验组对各项中医证候积分的改善作用均明显优于对照组(P<0.05)。(3)治疗后,试验组的BMI较治疗前明显降低(P<0.05),对照组的BMI较治疗前有降低趋势,但差异无统计学意义(P>0.05);组间比较,试验组对BMI的降低作用明显优于对照组(P<0.05)。(4)治疗后,2组患者的总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平均较治疗前降低(P<0.01),试验组患者的高密度脂蛋白胆固醇(HDL-C)水平较治疗前升高(P<0.01),对照组的HDL-C水平较治疗前有升高趋势,但差异无统计学意义(P>0.05);组间比较,试验组对TC和LDL-C水平的降低作用及对HDL-C水平的升高作用均明显优于对照组(P<0.05或P<0.01)。(5)肠道菌群方面,对照组厚壁菌门含量较健康人群及试验组上升(P<0.05),而试验组厚壁菌门含量较对照组明显下降(P<0.05),拟杆菌门和变形菌门含量较对照组明显升高(P<0.05)。【结论】鹧鸪茶可有效改善高脂血症痰浊阻遏证患者的中医证侯、体质量指数和血Objective To investigate the impact of Zhegu Tea on the hypolipidemic effect and intestinal flora in patients with hyperlipidemia(HLP)of blockage of turbid phlegm syndrome. Methods Forty patients with HLP of blockage of turbid phlegm syndrome were randomly divided into the trial group and the control group, with20 patients in each group. All of the patients underwent the exercises recommended by the guidelines for lowering lipid,and the trial group was given oral use of Zhegu Tea additionally. The treatment course lasted for a period of8 weeks. Before and after the intervention,the traditional Chinese medicine(TCM)syndrome scores,body mass index(BMI)and blood lipid indexes in the two groups were observed, and TCM syndrome efficacy in the two groups was also evaluated after treatment. Moreover,fresh feces were collected from the two groups of patients and from 10 healthy volunteers at the end of the treatment for testing the intestinal flora. Results (1)After 8 weeks of intervention,the overall effective rate of the trial group was 95.0%(19/20)and that of the control group was 15.0%(3/20),and the intergroup comparison showed that the TCM syndrome efficacy in the trial group was significantly superior to that in the control group(P<0.01).(2)After treatment,the scores of the TCM symptoms of obesity,swathing sensation of head,vomiting of phlegmatic fluid,tastelessness in the mouth and poor appetite in the trial group were improved compared with those before treatment(P<0.05 or P<0.01),while in the control group only the scores of obesity and tastelessness in the mouth were improved(P<0.05). The intergroup comparison showed that the effect on improving the TCM syndrome scores in the trial group was significantly superior to that in the control group(P<0.05).(3)After treatment,the BMI of the trial group was significantly decreased compared with that before treatment(P<0.05),while the BMI of the control group tended to decrease compared with that before treatment,but the difference was not statistically significant(P>0.

关 键 词：高脂血症 痰浊阻遏证 鹧鸪茶 体质量指数 血脂 肠道菌群 

分 类 号：R259.892[医药卫生—中西医结合]