药物负荷试验结合分层应变技术对冠心病患者左室心肌功能的定量评估  

Quantitative evaluation of left ventricular myocardial function in patients with coronary heart disease by drug loading test combined with the layer-specific strain technique

作　　者：高海叶 张璐[1] 张艳[1] 彭芮[1] 任凤霞[1] 邓爱云[1] Gao Hai-ye;Zhang Lu;Zhang Yan;Peng Rui;Ren Feng-xia;Deng Ai-yun(Gansu Provincial Key Laboratory of Cardiovascular Disease,Gansu Provincial Clinical Research Center for Cardiovascular Disease,Department of Cardiology,The First Hospital of Lanzhou University,Lanzhou 730000,china)

机构地区：[1]兰州大学第一医院心脏中心,甘肃省心血管病临床医学研究中心,甘肃省心血管疾病重点实验室,甘肃兰州730000

出　　处：《兰州大学学报（医学版）》2022年第12期69-73,共5页Journal of Lanzhou University（Medical Sciences）

基　　金：甘肃省自然科学基金资助项目(20JR10RA679)。

摘　　要：目的探讨药物负荷超声心动图结合分层应变技术诊断可疑冠心病患者的价值。方法选取2021年1月1日-12月31日就诊于兰州大学第一医院有胸痛症状的可疑冠心病患者60例,依据冠状动脉造影结果分为:明显狭窄组(A组,35例)和无明显狭窄组(B组,25例),比较2组患者间临床基线资料及超声心动图相关参数。结果A组患者吸烟状态、心肌酶、左室舒张末期容积大于B组,差异有统计学意义(P<0.05);在药物负荷峰值状态下,A组患者室壁运动积分指数及差值绝对值高于B组,心内膜层心肌整体应变、中层心肌整体应变、心外膜层心肌整体应变、各层心肌整体峰值应变静息-负荷变化梯度绝对值均低于B组,差异均具有统计学意义(P<0.05)。结论利用超声心动图结合多巴酚丁胺负荷试验技术,可以提高冠状动脉明显狭窄患者的诊断准确率。Objective To investigate the value of drug stress echocardiography combined with the layer-specific strain technique in the diagnosis of suspected coronary heart disease.Methods From January 1 to December 31,2021,60 patients with suspected coronary heart disease who had chest pain in The First Hospital of Lanzhou University were selected.According to the results of coronary angiography,they were divided into two groups:the obvious stenosis group(group A,35 patients)and non-obvious stenosis group(group B,25 patients).The indexes between the two groups were compared.Results The smoking status,myocardial enzymes and left ventricular end diastolic volume of patients in group A were greater than those in group B(P<0.05).Under the peak drug load state,the absolute value of the integral index and difference of the ventricular wall motion in group A was higher than that in group B,and the overall strain of the endocardial myocardium,overall strain of the medial myocardium,and overall strain of the epicardial myocardium were lower than those in group B,with a statistical differences(P<0.05).Conclusion Echocardiography combined with Dobutamine stress test can improve the diagnostic accuracy of patients with obvious coronary artery stenosis.

关 键 词：负荷超声心动图 分层应变技术 冠心病 

分 类 号：R445.1[医药卫生—影像医学与核医学]