丹参活性成分及制剂改善脑侧支循环及促进血管生成的药理作用研究进展  

Research progress in pharmacological effects of active components and preparations of Salvia miltiorrhiza on improving cerebral collateral circulation and promoting angiogenesis

作　　者：姚宇晴 陈璐 李德坤[2,3] 万梅绪 李智[2,3] 张燕欣 鞠爱春 YAO Yuqing;CHEN Lu;LI Dekun;WAN Meixu;LI Zhi;ZHANG Yanxin;JU Aichun(Hebei University of Traditional Chinese Medicine,Shijiazhuang 050200,China;Tianjin Tasly Pride Pharmaceutical Co.,Ltd.,Tianjin 300410,China;Tianjin Key Laboratory of Safety Evaluation Enterprise of Traditional Chinese Medicine Injections,Tianjin 300410,China)

机构地区：[1]河北中医学院,河北石家庄050200 [2]天津天士力之骄药业有限公司,天津300410 [3]天津市中药注射剂安全性评价企业重点实验室,天津300410

出　　处：《药物评价研究》2023年第1期216-224,共9页Drug Evaluation Research

摘　　要：丹参Salvia miltiorrhiza作为临床上常用的活血化瘀药,其药理作用广泛,尤其在治疗脑血管病上方面效果良好,其主要活性成分和制剂均具有良好的改善脑侧支循环及促进血管生成的药理作用。通过对改善脑侧支循环和血管生成的丹参活性成分(丹参素类和丹参酮类)和丹参类制剂(丹参注射剂如注射用丹参多酚酸、注射用丹参多酚酸盐、丹红注射液及口服制剂如复方丹参滴丸、复方丹参片、复方丹参颗粒等)的药理作用进行综述,为临床合理用药以及与侧支循环和血管生成相关的脑血管病治疗提供依据。Salvia miltiorrhiza, is a common using clinical drug to invigorate the circulation of blood and dispersing blood stasis, has a wide range of pharmacological effects, especially effective in the treatment of cerebrovascular diseases, and its main active ingredients and preparations have good pharmacological effects on improving cerebral collateral circulation and promoting angiogenesis. By reviewing the pharmacological effects of the active ingredients, which to improve cerebral collateral circulation and angiogenesis(tanshinin and tanshinone) and salvia preparations(danshen injections such as Danshen Polyphenolic Acid for Injection, Danshen Polyphenolate for Injection, Danshen Injection and oral preparations such as compound Danshen Drop Pills,Compound Danshen Tablets, Compound Danshen Granules, etc.), this paper provides a basis for clinical rational drug using and the treatment of cerebrovascular diseases related to collateral circulation and angiogenesis.

关 键 词：丹参 丹参类制剂 侧支循环 血管生成 脑血管疾病 药理作用 

分 类 号：R285.5[医药卫生—中药学]