抗磷脂抗体与复发性自然流产和子痫前期的相关性分析  

Correlation of antiphospholipid antibodies with recurrent spontaneous abortion and preeclampsia

作　　者：石雯茜 段忠亮[1] 李翠[1] 应春妹[1] SHI Wen-xi;DUAN Zhong-liang;LI Cui;YING Chun-mei(Obstetrics and Gynecology Hospital of Fudan University,Shanghai,20001l,China)

机构地区：[1]复旦大学附属妇产科医院,上海200011

出　　处：《中国妇幼保健》2023年第3期473-476,共4页Maternal and Child Health Care of China

基　　金：上海市卫生和计划生育委员会科研课题(20164Y0105)。

摘　　要：目的 分析抗磷脂抗体与复发性自然流产和子痫前期的相关性,为临床检查和诊治提供数据支持。方法 选取2019年1月—2021年5月在复旦大学附属妇产科医院分娩且无任何不良孕产史的女性为研究对象,比较复发性自然流产、子痫前期患者抗心磷脂抗体(ACA)和抗β2糖蛋白1抗体(Anti-β2-GPI)的IgA、IgG及IgM抗体阳性率。结果 复发性自然流产组ACA总阳性率为8.99%(102/1 134),Anti-β2-GPI总阳性率为10.41%(118/1 134)。子痫前期组ACA总阳性率为19.77%(17/86),Anti-β2-GPI总阳性率为18.60%(16/86)。对照组ACA总阳性率为5.95%(30/504),Anti-β2-GPI总阳性率为7.54%(38/504)。ACA和Anti-β2-GPI的IgA型抗体明显偏少,IgG和IgM型抗体偏多。复发性自然流产组ACA总阳性率为8.99%,显著高于对照组,差异有统计学意义(P<0.05);Anti-β2-GPI总阳性率为10.41%,与对照组比较差异无统计学意义(P>0.05)。ACA、Anti-β2-GPI IgM型抗体阳性率均显著高于对照组,差异均有统计学意义(均P<0.05)。子痫前期组ACA总阳性率为19.77%,Anti-β2-GPI总阳性率为18.60%,均显著高于对照组,差异均有统计学意义(均P<0.05)。子痫前期组ACA IgM型抗体阳性率显著高于对照组,差异有统计学意义(P<0.05)。子痫前期组Anti-β2-GPI IgG型抗体阳性率显著高于对照组,差异有统计学意义(P<0.05)。结论 ACA和Anti-β2-GPI与复发性自然流产、子痫前期的发生有相关性,对孕妇不同型别的抗磷脂抗体检查十分必要。Objective To investigate the correlation between antiphospholipid antibodies, recurrent spontaneous abortion and preeclampsia, to provide data support for the clinical examination, diagnosis and treatment.Methods Women who gave birth in Obstetrics and Gynecology Hospital of Fudan University from January 2019 to May 2021 without any adverse pregnancy history were selected as control. The positive rates of IgA, IgG and IgM antibodies against anticardiolipin antibody(ACA) and anti-β2-glycoprotein-1 antibody(Anti-β2-GPI) in patients with recurrent spontaneous abortion and preeclampsia were compared.Results The total positive rates of ACA and Anti-β2-GPI in recurrent spontaneous abortion group were 8.99%(102/1134) and 10.41%(118/1134). The total positive rates of ACA and Anti-β2-GPI in preeclampsia group were 19.77%(17/86) and 18.60%(16/86) respectively. The positive rates of ACA and Anti-β2-GPI were 5.95%(30/504) and 7.54%(38/504) in the control group. The IgA type antibodies of ACA and Anti-β2-GPI were short, while the IgG and IgM type antibodies were in the majority. The total positive rate of ACA in recurrent spontaneous abortion group was 8.99%, which was significantly higher than that in control group(P<0.05). The total positive rate of Anti-β2-GPI was 10.41%, and there was no significant difference between the two group(P>0.05). The positive rates of IgM antibody against ACA and Anti-β2-GPI were significantly higher than those in control group, and the differences were statistically significant(P<0.05). The total positive rates of ACA and Anti-β2-GPI in preeclampsia group were 19.77% and 18.60%, respectively, which were significantly higher than those in control group, with statistical significance(all P<0.05). The positive rate of ACA IgM antibody in preeclampsia group was significantly higher than that in control group(P<0.05). The positive rate of Anti-β2-GPI IgG antibody in preeclampsia group was significantly higher than that in control group(P<0.05).Conclusion ACA and Anti-β2-GPI are associated

关 键 词：抗磷脂抗体 复发性自然流产 子痫前期 

分 类 号：R714.21[医药卫生—妇产科学]