景天三七抗动脉粥样硬化作用  

Study on the Anti-Atherosclerosis Effect of Sedum Aizoon L.

作　　者：朱博杰 潘天箫 黄子冬[1] 凌桂梅[1] 庞英华[1] 时宗泽[1] 李娜[1] 林嘉茜 Zhu Bojie;Pan Tianxiao;Huang Zidong;Ling Guimei;Pang Yinghua;Shi Zongze;Li Na;Lin Jiaqian(People's Hospital of Baise,Baise 533000,China)

机构地区：[1]百色市人民医院,广西百色533000

出　　处：《亚太传统医药》2023年第1期41-44,共4页Asia-Pacific Traditional Medicine

基　　金：百色市科学研究和技术开发计划——“市校科技合作”项目[百科技20170813]。

摘　　要：目的:研究景天三七抗动脉粥样硬化作用。方法:将雄性新西兰大白兔随机分成4组,分别为实验模型对照组、辛伐他汀组、景天三七组、空白对照组,空白对照组予普通饲料喂养10周,其余3组予高脂饲料喂养10周造模,第10周后,空白对照组与实验模型对照组每天灌胃等量生理盐水,辛伐他汀组及景天三七组分别予辛伐他汀、景天三七灌胃,1次/d,连续给药10周后收集兔子血清,检测血清中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平,对兔子腹主动脉进行HE染色,观察其组织结构形态。结果:第10周时,与空白对照组比较,其他3组兔子血清中TC、TG、HDL-C、LDL-C水平均明显升高(P<0.05),说明兔子动脉粥样硬化模型建立成功。20周后,与实验模型对照组比较,景天三七组兔子血清中TG、LDL-C水平明显降低(P<0.05),HDL-C明显升高(P<0.05),TC水平无明显差异(P>0.05);与辛伐他汀组比较,景天三七组兔子血清中TC、TG、HDL-C、LDL-C水平无明显差异(P>0.05)。景天三七组治疗前后比较,TG、LDL-C水平明显降低(P<0.05),TC、HDL-C水平无明显差异(P>0.05)。兔子腹主动脉HE染色结果显示,与空白对照组比较,实验模型对照组、辛伐他汀组与景天三七组兔子腹主动脉有明显动脉粥样硬化斑块形成,且病变范围及程度明显;辛伐他汀组与景天三七组腹主动脉粥样硬化斑块面积较实验模型对照组减少。结论:景天三七一定程度上能够抑制兔子粥样硬化斑块形成,降低TG、LDL-C,起到降脂作用。Objective:Study on the anti-atherosclerosis effect of Sedum aizoon L..Methods:Male New Zealand white rabbits were randomly divided into blank control group, experimental model control group, simvastatin group, and Sedum aizoon L.group.Blank control group was fed with ordinary diet for 10 weeks, and other groups were fed with high-fat diet for 10 weeks for modeling.After the 10 th week, the blank control group and the model control group were given the same amount of normal saline by gavage every day, and the simvastatin group and the Sedum aizoon L.group were respectively given simvastatin and Sedum aizoon L.by gavage, once a day.Rabbit serum and abdominal aorta were collected 10 weeks after administration to detect serum total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol(HDL-C).The rabbit abdominal aorta was stained with HE to observe its tissue structure and morphology.Results:After 10 weeks, compared with the blank control group, the levels of serum TC,TG,HDL-C and LDL-C in the other three groups were significantly increased(P<0.05),which indicates the rabbit atherosclerosis model was successfully established.After 20 weeks, compared with the model control group, the levels of serum TG and LDL-C in the Sedum aizoon L.group were significantly decreased(P<0.05),HDL-C was significantly increased(P<0.05),while there was no significant difference in TC(P>0.05).Compared with the simvastatin group, there was no significant difference in the levels of serum TC,TG,HDL-C and LDL-C in the Sedum aizoon L.group(P>0.05).Compared with the 10 th week, the levels of TG and LDL-C in the 20 th week were significantly decreased(P<0.05),while there was no significant difference in TC and HDL-C(P>0.05).According to the results of HE staining, the abdominal aorta plaque formation was obvious in model control, simvastatin and Sedum aizoon L.group comparing with the blank control group, and the lesion range and degree were obvious;Compared with the model control g

关 键 词：景天三七 动脉粥样硬化 血脂 

分 类 号：R285.5[医药卫生—中药学]