甲状腺激素在肺纤维化中的作用和机制研究进展  

Research progress of thyroid hormone in pulmonary fibrosis

作　　者：刘保岩 王勇 刘燕[1] 李娟[1] 崔萍[1] 贺今 Liu Baoyan;Wang Yong;Liu Yan;Li Juan;Cui Ping;He Jin(Shandong Academy of Occupational Health and Occupational Medicine(Shandong Province Hospital of Occupational Diseases Hospital of Shandong First Medical University),Jinan 250062,China)

机构地区：[1]山东省职业卫生与职业病防治研究院(山东第一医科大学附属山东省职业医院),济南250062

出　　处：《中华劳动卫生职业病杂志》2023年第1期62-66,共5页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：山东省中医药科技项目(2021Q082);山东省自然科学基金面上项目(ZR2021MH178);济南市科技计划(202019203);国家科技重大专项(新药创制重大专项)(2018ZX09711001-011)。

摘　　要：肺纤维化是多种异质性肺间质疾病的终末期,以肌成纤维细胞的过度增殖、细胞外基质的沉积和肺实质的破坏为特征。甲状腺和肺来源于同一内胚层细胞,甲状腺激素影响慢性阻塞性肺疾病、肺癌等多种肺疾病的发生、发展和预后。本文就甲状腺激素在肺纤维化的作用和机制进行综述,以期为甲状腺激素在矽肺中的作用和机制研究提供新思路。Pulmonary fibrosis is end-stage of variety of heterogeneous interstitial lung disease,characterizedby excessive proliferation of fibroblasts and extracellular matrix deposition and destruction of lung parenchyma.Thyroid and lung are derived from the same endodermal cells,thyroid hormone affect the occurrence、development and prognosis of the chronic obstructive pulmonary disease,lung cancer and other lung diseases,This article reviews the role and mechanism of thyroid hormone in pulmonary fibrosis in order to provide new idea for the study of the role and mechanism of thyroid hormone in silicosis.

关 键 词：肺纤维化 甲状腺激素 作用 机制 矽肺 

分 类 号：R563[医药卫生—呼吸系统]