桑白利湿汤对肺癌伴咳嗽患者痰中P物质及降钙素基因相关肽水平的影响  

Effect of Sangbai Lishi decoction on the level of substance P and calcitonin gene-related peptide in sputum of lung cancer patients with cough

作　　者：刘利娜 陈后良 陶玉[1] 黄兆明[1] 李献超[2] LIU Lina;CHEN Houliang;TAO Yu;HUANG Zhaoming;LI Xianchao(Department of Oncology,Wenzhou Hospital of Traditional Chinese Medicine,Wenzhou 325000,Zhejiang,China;Department of Respiration,Wenzhou Hospital of Traditional Chinese Medicine,Wenzhou 325000,Zhejiang,China)

机构地区：[1]温州市中医院肿瘤科,浙江温州325000 [2]温州市中医院呼吸科,浙江温州325000

出　　处：《中国现代医生》2023年第5期64-67,共4页China Modern Doctor

基　　金：浙江省中医药科技计划项目(2017ZB086)。

摘　　要：目的探讨桑白利湿汤对肺癌伴咳嗽(湿热蕴结证)患者痰中P物质(substance P,SP)及降钙素基因相关肽(calcitonin gene-related peptide,CGRP)水平的影响。方法选取2019年6月至2021年8月温州市中医院收治的肺癌伴咳嗽患者82例作为研究对象,采用随机数字表法分成对照组(n=41)和观察组(n=41)。对照组予以常规西药治疗,观察组予以桑白利湿汤联合常规西药进行治疗。比较治疗后两组患者的咳嗽评分、痰中SP及CGRP水平、炎症因子水平、治疗后并发症发生率。结果治疗后,观察组的咳嗽评分、SP及CGRP水平均显著低于对照组患者,差异有统计学意义(P<0.05);治疗后,观察组白细胞介素-6(interleukin-6,IL-6)、C反应蛋白(C-reactive protein,CRP)水平低于对照组,差异有统计学意义(P<0.05);治疗后观察组出现肺部感染、支气管扩张、呼吸衰竭及肺不张等肺部并发症的总发生率低于对照组,差异有统计学意义(P<0.05)。结论桑白利湿汤治疗肺癌伴咳嗽患者(湿热蕴结证)的临床效果显著,有效改善患者的临床症状,降低痰中P物质及降钙素基因相关肽水平,减轻炎症反应,减少并发症的发生,值得推广应用。Objective To investigate the effect of Sangbai Lishi decoction on substance P(SP)and calcitonin gene-related peptide(CGRP)in sputum of patients with lung cancer complicated with cough(damp heat accumulation syndrome).Methods A total of 82 patients with lung cancer with cough admitted to Wenzhou Hospital of Traditional Chinese Medicine from June 2019to August 2021 were selected for the study,and were divided into the control group(n=41)and the observation group(n=41)using the random number table method.The control group was treated with conventional chemical drug,while the observation group was treated with Sangbai Lishi decoction combined with chemical drug.The cough scores,the levels of SP and CGRP in sputum,the levels of inflammatory factors and the incidence of complications were compared between the two groups after treatment.Results After treatment,the scores of cough,the levels of SP and CGRP in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of interleukin-6(IL-6)and C-reactive protein(CRP)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The total incidence of pulmonary complications such as pulmonary infection,bronchiectasis,respiratory failure and atelectasis in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Sangbai Lishi decoction has a significant clinical effect in the treatment of lung cancer patients with cough(damp heat accumulation syndrome).It can effectively improve the clinical symptoms of the patients,reduce the levels of SP and CGRP in the sputum,alleviate the inflammatory reaction and reduce the occurrence of complications,it is worth popularizing and applying.

关 键 词：桑白利湿汤 肺癌伴咳嗽 痰中P物质 降钙素基因相关肽 炎症因子水平 疗效 

分 类 号：R256.1[医药卫生—中医内科学]