鱼类载脂蛋白B基因的研究进展  

Research progress of apolipoprotein B gene in fish

作　　者：秦文皓 杨朝辉 李庆 庞晨杨 刘雨倩 杜雪地 董小敬 QIN Wenhao;YANG Chaohui;LI Qing;PANG Chenyang;LIU Yuqian;DU Xuedi;DONG Xiaojing(College of Animal Science and Technology,Yangzhou University,Yangzhou 225100,China;Yangzhou Guyun Ecological Agriculture Development Co.,Ltd.,Yangzhou 225200,China)

机构地区：[1]扬州大学动物科学与技术学院,江苏扬州225100 [2]扬州古韵生态农业发展有限公司,江苏扬州225200

出　　处：《黑龙江畜牧兽医》2023年第3期18-25,30,共9页Heilongjiang Animal Science And veterinary Medicine

基　　金：国家自然科学基金项目(31802310)。

摘　　要：载脂蛋白B(apoB)广泛存在于各种脊椎动物中,是脂蛋白的重要组成成分,在脂质的代谢中发挥重要作用。鱼类apoB具有与哺乳动物类似的功能,但存在不同的亚型,并且在氨基酸序列和载脂蛋白B mRNA编辑酶-催化多肽样复合物1(APOBEC1)编辑机制上与哺乳动物存在较大差异。文章对鱼类apoB的分子结构、生物学功能及影响鱼类apoB基因表达的因素等方面的研究进展进行了综述,旨在为系统研究apoB基因调控鱼类脂质代谢的机制提供参考。Apolipoprotein B(apoB)is widely found in various vertebrates and is an important component of lipoprotein,which plays an important role in lipid metabolism.ApoB in fish has similar function to that in mammals,but different subtypes exist,and there are significant differences in amino acid sequence and APOBEC1 editing mechanism between fish and mammals.In this review,the molecular structure,biological function and factors affecting the expression of apoB gene in fish were reviewed,in order to provide a reference for the systematic study on the mechanism of apoB gene regulating lipid metabolism in fish.

关 键 词：鱼类 载脂蛋白B 基因 亚型 结构特点 脂质转运 

分 类 号：S917[农业科学—水产科学]