孕早期邻苯二甲酸酯和多环芳烃暴露与早产的队列研究  

Association of phthalate and polycyclic aromatic hydrocarbon exposure during early pregnancy with premature delivery:A cohort study

作　　者：陈瑾 欧子暄 冯琪源 彭恋淇 陈晋宇 熊凡 刘春艳[1] 赵凯 章慧平[1] 商学军 方毅为 CHEN Jin;OU Zi-xuan;FENG Qi-yuan;PENG Lian-qi;CHEN Jin-yu;XIONG Fan;LIU Chun-yan;ZHAO Kai;ZHANG Hui-ping;SHANG Xue-jun;FANG Yi-wei(Research Institute of Reproductive Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China;Department of Urology,Jinling Hospital,Nanjing University School of Medicine/General Hospital of Eastern Theater Command,Nanjing,Jiangsu 210002,China)

机构地区：[1]华中科技大学同济医学院生殖健康研究所,湖北武汉430030 [2]南京大学医学院附属金陵医院/东部战区总医院泌尿外科,江苏南京210002

出　　处：《中华男科学杂志》2022年第10期873-880,共8页National Journal of Andrology

基　　金：国家重点研发计划项目(2018YFC1004300,2018YFC1004304)~~。

摘　　要：目的:探究孕妇邻苯二甲酸酯(PAE)和多环芳烃(PAH)暴露和早产的关系。方法:以湖北省妇幼保健院孕早期检查821例孕妇为研究对象,基线问卷调查、收集晨尿并随访至妊娠结局,定量分析尿样PAE和PAH代谢物各10种。采用曼惠特尼U检验、χ^(2)检验、Logistic回归分析。结果:PAE中5种暴露物检出率>80%,仅邻苯二甲酸单卞酯(MBzP)检出率<50%。PAH中5种暴露物的检出率>80%,其中3-羟基菲(3-OHPHE)检出率最高,为86.91%,仅4-羟基菲(4-OHPHE)检出率<50%。Logistic回归分析发现MBzP高暴露组的孕妇早产的风险高于相应的低暴露组(aOR=2.26,95%CI:1.17,4.39)。结论:MBzP高水平暴露可能是导致早产发生的高危因素。Objective:To explore the relationship of the exposure to phthalate esters(PAE)and polycyclic aromatic hydrocarbons(PAH)with clinical premature delivery during early pregnancy.Methods:We conducted a baseline questionnaire survey among 821 pregnant women undergoing prenatal examination in Hubei Provincial Maternal and Child Health Care Hospital,collected their morning urine samples and followed them up to the outcomes of pregnancy.We quantitatively analyzed 10 PAE and 10 PAH metabolites in the urine samples,followed by Mann-Whitney U test,chi-square test,and logistic regression analysis.Results:The detection rate of the 5 factors exposed to was>80%while that of phthalic acid monobenzyl ester(MBzP)was<50% in PAEs;that of the 5 factors exposed to was>80%,that of 3-hydroxyphene(3-OHPHE)was 86.91%while that of 4-hydroxyphene(4-OHPHE)was<50% in PAHs.Logistic regression analysis showed that the risk of premature delivery was higher in the high MBzP-than in the low MBzP-exposure group(aOR=2.26,95%CI:1.17-4.39).Conclusion:High MBzP-exposure may be a risk factor for premature delivery.

关 键 词：邻苯二甲酸酯 多环芳烃 早产 

分 类 号：R714.21[医药卫生—妇产科学]