孕中晚期血清水通道蛋白1和白细胞介素37水平在子痫前期孕妇中的临床意义  

Clinical significance of serum aquaporin 1 and interleukin-37 levels in pregnant women with preeclampsia during the second and third trimester

作　　者：陈琛[1] 陈东颖[1] 项明飞 CHEN Chen;CHEN Dong-ying;XIANG Ming-fei(Department of Obstetrics and Gynecology,the People's Hospital of Bozhou,Bozhou Anhui 236800,China;Department of Laboratory Medicine,the People's Hospital of Bozhou,Bozhou Anhui 236800,China)

机构地区：[1]亳州市人民医院妇产科,安徽亳州236800 [2]亳州市人民医院检验科,安徽亳州236800

出　　处：《临床和实验医学杂志》2023年第1期50-54,共5页Journal of Clinical and Experimental Medicine

基　　金：中国红十字基金会“医学赋能-领航精英科研项目”(编号:XM_HR_YXFN_2021_05_24)。

摘　　要：目的 探讨孕中晚期血清水通道蛋白1(APQ1)和白细胞介素37(IL-37)水平在子痫前期孕妇中的临床意义。方法 前瞻性选取2019年1月至2021年12月亳州市人民医院收治的子痫前期孕妇65例,根据疾病严重程度,将患者分为轻度子痫前期组(n=38)与重度子痫前期者(n=27);根据发病先后将患者分为早发型子痫前期(n=34)与晚发型子痫前期(n=31),选择同期来亳州市人民医院孕检的正常孕妇60例作为对照组。比较轻度子痫前期组、重度子痫前期组患者与对照组的血清APQ1和IL-37水平;比较早发型子痫前期、晚发型子痫前期患者与对照组的血清APQ1和IL-37水平;分析子痫前期与对照组孕妇的临床检测指标水平;分析子痫前期孕妇的血清APQ1和IL-37水平与各临床指标的相关性及对子痫前期的预测价值。结果 3组组间血清APQ1和IL-37水平比较,差异均有统计学意义(P<0.05),对照组、轻度子痫前期组及重度子痫前期组APQ1水平呈低到高趋势,IL-37水平呈高到低趋势。子痫前期组的血清白蛋白、总蛋白明显低于对照组,尿酸、尿氮素、胱抑素C、肌酐、乳酸脱氢酶、24 h尿蛋白含量均明显高于对照组,差异均有统计学意义(P<0.05)。血清APQ1与血清白蛋白呈负相关(P<0.05),与胱抑素C、24 h尿蛋白呈正相关(P<0.05);血清IL-37与血清白蛋白呈正相关(P<0.05),与胱抑素C、24 h尿蛋白呈负相关(P<0.05)。ROC曲线结果表明,血清APQ1以26.34 ng/mL作为子痫前期预测的临界值,以36.88 ng/mL作为区分轻度子痫、重度子痫的临界值;IL-37以120.45 ng/mL作为子痫前期预测的临界值,以67.89 ng/mL作为区分轻度子痫、重度子痫的临界值。结论 血清APQ1升高、IL-37降低与子痫前期的发生、发展具有相关性,且两者均可预测子痫前期,对于子痫前期具有重要价值。Objective To investigate the clinical significance of serum aquaporin 1(APQ1) and interleukin-37(IL-37) levels in pregnant women with preeclampsia during the second and third trimester. Methods A total of 65 pregnant women who came to the People’s Hospital of Bozhou from January 2019 to December 2021 were prospectively selected. According to the severity of the disease, the 65 patients were divided into mild preeclampsia group(n=38) and severe preeclampsia(n=27), the patients were divided into early-onset preeclampsia(n=34) and late-onset preeclampsia(n=31) according to the onset order, and 60 normal pregnant women who came to Bozhou People’s Hospital for pregnancy examination during the same period were selected as the control group. The levels of serum APQ1 and IL-37 in patients with mild preeclampsia, severe preeclampsia and the control group were compared;the levels of serum APQ1 and IL-37 levels in patients with early-onset, late-onset preeclampsia and the control group were compared;the levels of clinical test indexes in pregnant women with preeclampsia and the control group was analyzes;the correlation between the serum APQ1 and IL-37 levels of pre eclampsia pregnant women and various clinical indicators and the predictive value of pre eclampsia were analyzed. Results There were statistically significant differences in serum APQ1 expression and IL-37 level among the three groups(P<0.05), APQ1 expression in the control group, mild preeclampsia group and severe preeclampsia group showed a low to high trend, and IL-37 level showed a high to low trend. The levels of serum albumin and total protein in preeclampsia group were significantly lower than those in the control group, and the levels of uric acid, urinary nitrogen, cystatin C, creatinine, lactate dehydrogenase and 24-hour urinary protein were significantly higher than those in the control group, the differences were statistically significant(P<0.05). Serum APQ1 was negatively correlated with serum albumin(P<0.05), and positively correlated with cyst

关 键 词：水通道蛋白1 白细胞介素37 子痫前期 24 h尿蛋白 疾病严重程度 

分 类 号：R714.244[医药卫生—妇产科学]