基于磁场复制器的脑深部磁刺激方法研究  

Study on deep brain magnetic stimulation method based on magnetic replicator

作　　者：吴念霜 刘海军 王家豪 张丞[1,2] 吴昌哲 霍小林 张广浩[1,2] WU Nianshuang;LIU Haijun;WANG Jiahao;ZHANG Cheng;WU Changzhe;HUO Xiaolin;ZHANG Guanghao(Beijing Key Laboratory of Bioelectromagnetism,Institute of Electrical Engineering,Chinese Academy of Sciences,Beijing 100190,P.R.China;School of Electronics,Electrical and Communication Engineering,University of Chinese Academy of Sciences,Beijing 100049,P.R.China;HUGER Medical Instrument Co.,Ltd,Shanghai 201619,P.R.China)

机构地区：[1]中国科学院电工研究所、生物电磁学北京市重点实验室,北京100190 [2]中国科学院大学、电子电气与通信工程学院,北京100049 [3]上海成运医疗器械股份有限公司,上海201619

出　　处：《生物医学工程学杂志》2023年第1期1-7,共7页Journal of Biomedical Engineering

基　　金：国家自然科学基金(51977205,52077209)。

摘　　要：现有神经调控技术可以实现全脑刺激或皮层精准刺激,但高聚焦性的脑深部刺激一直是该领域的技术瓶颈。本文以近年来出现的负磁导率理论为基础,建立磁场复制器仿真模型,研究脑深部感应电场分布,探讨其深部聚焦的可能性,并与传统磁刺激方法进行对比。仿真结果表明,单个的磁场复制器实现了远程磁源的建立,与同样位置条件下的传统刺激方法相比,前者的感应电场较小且随距离出现骤减,通过磁场复制器的叠加可增加感应电场强度并提高聚焦性,减少外围导线数目仍可保证良好的聚焦性。本文建立的磁场复制器模型为脑深部精准刺激提供了新的思路,在未来可以与神经调控技术结合起来,为最终实现临床应用打下基础。Existing neuroregulatory techniques can achieve precise stimulation of the whole brain or cortex, but high-focus deep brain stimulation has been a technical bottleneck in this field. In this paper, based on the theory of negative permeability emerged in recent years, a simulation model of magnetic replicator is established to study the distribution of the induced electric field in the deep brain and explore the possibility of deep focusing, which is compared with the traditional magnetic stimulation method. Simulation results show that a single magnetic replicator realized remote magnetic source. Under the condition of the same position and compared with the traditional method of stimulating, the former generated smaller induced electric field which sharply reduced with distance. By superposition of the magnetic field replicator, the induced electric field intensity could be increased and the focus could be improved,reducing the number of peripheral wires while guaranteeing good focus. The magnetic replicator model established in this paper provides a new idea for precise deep brain stimulation, which can be combined with neuroregulatory techniques in the future to lay a foundation for clinical application.

关 键 词：经颅磁刺激 经颅电刺激 负磁导率 聚焦性 脑深部刺激 

分 类 号：R318[医药卫生—生物医学工程]