6,7-二羟基香豆素温敏表面分子印迹材料制备及吸附性能  

Preparation and Adsorption Properties of 6,7-Dihydroxycoumarin Thermosensitive Surface Molecularly Imprinted Polymer

作　　者：钟海艺 罗健伟 李俊潮 蔡锦云 ZHONG Hai-yi;LUO Jian-wei;LI Jun-chao;CAI Jin-yun(College of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530200,China)

机构地区：[1]广西中医药大学药学院,广西南宁530200

出　　处：《化学试剂》2023年第3期61-66,共6页Chemical Reagents

基　　金：广西自然科学基金项目(2019GXNSFBA245088);广西中医药大学校级科研项目(2018QN006);广西中医药大学引进博士科研启动基金项目(2017BS034)。

摘　　要：以6,7-二羟基香豆素为模板分子,纳米SiO_(2)为表面载体,丙烯酰胺(AM)为功能单体,引入温敏单体N-异丙基丙烯酰胺(NIPAM),二甲基丙烯酸乙二醇酯(EGDMA)做交联剂,采用沉淀聚合法制备6,7-二羟基香豆素温敏表面分子印迹聚合物(T-SMIPs)。红外光谱(FT-IR)和扫描电镜(SEM)对聚合物结构与形貌进行了表征验证;吸附性能研究显示,所得MIP2能有效地对6,7-二羟基香豆素进行选择性吸附,当吸附液浓度为0.8 mg/mL时,吸附量可达21.85 mg/g,吸附过程与Langmuir和Freundlich模型相符;此外,印迹材料具有一定的温度响应性,降低温度有利于吸附。该研究可为天然药物中香豆素类成分的分离纯化、富集提供新的方法与思路。6,7-Dihydroxycoumarin thermal-sensitive surface molecularly imprinted polymers(T-SMIPs)were synthesized by precipitation polymerization which containing nano silica as a surface carrier,6,7-dihydroxycoumarin as a template,acrylamide(AM)as a functional monomer,N-isopropylacrylamide(NIPAM)as a temperature sensitive monomer and ethylene glycol dimethacrylate(EGDMA)as a crosslinker.The structure and morphology of the polymers were characterized by FT-IR and SEM.Static adsorption demonstrated that these imprinted polymers possessed well specific adsorption properties for 6,7-dihydroxycoumarin.The adsorbing capacity reached 21.85 mg/g when concentration of 6,7-dihydroxycoumarin was 0.8 mg/mL for MIP2,and the adsorption process accorded with Langmuir and Freundlich model.The MIP2 also exhibited temperature responsive behavior,which had a higher adsorption capacity at low temperature.This study could provide some new thoughts and methods to separate and purify coumarin from natural medicines.

关 键 词：分子印迹聚合物 表面印迹 香豆素 温敏 吸附 

分 类 号：O631.1[理学—高分子化学]