胆红素纳米颗粒的药理作用研究进展  

Research progress on pharmacological effects of bilirubin nanoparticles

作　　者：乔婷婷 张志宏[2] 周俊发 叶仕高 曾元宁 王秋红 QIAO Tingting;ZHANG Zhihong;ZHOU Junfa;YE Shigao;ZENG Yuanning;WANG Qiuhong(Technical Research Center for Standardized Processing of Chinese Herbal Medicine Decoction Pieces,School of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou 510006,China;Key Laboratory of Basic and Application Research of Beiyao,Ministry of Education,Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]广东药科大学中药学院/广东省中药饮片规范化炮制工程技术研究中心,广州510006 [2]黑龙江中医药大学教育部北药基础与应用研究重点实验室,哈尔滨150040

出　　处：《中国药房》2023年第5期631-635,共5页China Pharmacy

基　　金：广东省重点领域研发计划项目(No.2020B111112-0002)。

摘　　要：胆红素具有良好的抗炎、抗氧化和免疫调节作用,但由于其水溶性差、生物利用度低,极大地限制了临床应用。研究人员将胆红素开发成各种纳米颗粒,借助剂型优势有效消除了胆红素溶解性低的限制,使其能够最大化地发挥抗炎、抗氧化、调节免疫等药理活性。胆红素纳米颗粒在多种胃肠道疾病、肝肾疾病、皮肤疾病、自身免疫性疾病、胰岛移植以及肿瘤的靶向治疗(既可直接抗肿瘤,又可作为药物递送系统)中均具有巨大的应用潜力。对胆红素纳米制剂的研究将推动胆红素的临床应用和相关的新药研发。Bilirubin has good anti-inflammatory,antioxidant and immunomodulatory effects,but its poor water solubility and low bioavailability greatly limit its clinical application.Researchers have developed bilirubin into various nanoparticles,which effectively eliminate the limitation of low solubility of bilirubin with the advantage of dosage form,so that they can maximize its pharmacological activities such as anti-inflammatory,anti-oxidation and immune regulation.Bilirubin nanoparticles have great application potential in a variety of gastrointestinal diseases,liver and kidney diseases,skin diseases,autoimmune diseases,islet transplantation and targeted therapy of tumors(both as a direct anti-tumor drug and as a drug delivery system).The study of bilirubin nanoparticles will promote the clinical application of bilirubin and the development of related new drugs.

关 键 词：胆红素 纳米颗粒 抗炎 抗氧化 免疫调节 抗肿瘤 靶向治疗 

分 类 号：R965[医药卫生—药理学] R283.6[医药卫生—药学]