观察地西他滨联合复方皂矾丸对骨髓异常增生综合征的临床疗效以及对其机体炎症、生存质量的影响  

Clinical efficacy of decitabine combined with compound Zaofan pills on myelodysplastic syndrome and its effect on inflammation and quality of life

作　　者：刘淑芳[1] 李丽娜 杨国 LIU Shu-fang;LI Li-na;YANG Guo(Department of Hematology,the First Affiliated Hospital of Hainan Medical College,Haikou Hainan 570100,China)

机构地区：[1]海南医学院第一附属医院血液内科,海南海口570100

出　　处：《临床和实验医学杂志》2023年第2期161-164,共4页Journal of Clinical and Experimental Medicine

基　　金：海南省卫生健康行业科研项目(编号:21A200060)。

摘　　要：目的探究地西他滨联合复方皂矾丸对骨髓增生异常综合征(MDS)的临床疗效以及对其机体炎症、生存质量的影响。方法前瞻性选取2020年1月至2022年5月在海南医学院第一附属医院血液内科接受治疗的MDS患者120例,采用随机数表法分为观察组(n=60)和对照组(n=60)。对照组患者采用地西他滨治疗,观察组在其基础上联合复方皂矾丸治疗,4周为1个疗程,连续治疗4个疗程。对比两组的治疗疗效、不良反应,治疗前后外周血中性粒细胞绝对值(NEU)、白细胞计数(WBC)、血红蛋白、血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、血管内皮生长因子(VEGF)以及生命质量核心问卷(QLQ-C30)情况。结果观察组总缓解率为60.00%,显著高于对照组的40.00%,不良反应总发生率为10.00%,显著低于对照组的28.33%,差异均有统计学意义(P<0.05)。治疗后,两组外周血NEU、WBC、血红蛋白均升高,且观察组NEU、WBC、血红蛋白水平为(1.54±0.36)×10^(9)/L、(2.89±0.21)×10^(9)/L、(93.66±10.27)g/L,均高于对照组[(1.31±0.28)×10^(9)/L、(2.36±0.15)×10^(9)/L、(75.26±9.14)g/L],差异均有统计学意义(P<0.05)。治疗后,两组血清TNF-ɑ、IL-6、VEGF水平均较治疗前降低,且观察组TNF-ɑ、IL-6、VEGF浓度为(0.89±0.21)ng/mL、(34.66±7.61)pg/mL、(182.24±15.68)ng/L,均低于对照组[(1.05±0.21)ng/mL、(39.04±2.97)pg/mL、(249.36±27.51)ng/L],差异均有统计学意义(P<0.05)。治疗后,两组QLQ2C-30各项子量表得分均较治疗前降低,且观察组QLQ2C30得分低于对照组,差异均有统计学意义(P<0.05)。结论地西他滨联合复方皂矾丸可有效改善MDS临床症状,改善患者的机体炎症以及生存质量,降低并发症发生,相较于地西他滨单药治疗效果更佳。Objective To explore the clinical efficacy of decitabine combined with compound Zaofan pills on myelodysplastic syndrome(MDS)and its effect on inflammation and quality of life.Methods From January 2020 to May 2022,120 patients with MDS who were treated in the Department of Hematology,the First Affiliated Hospital of Hainan Medical College were prospectively selected,and they were divided into an observation group(n=60)and a control group(n=60)by random number table method.The patients in the control group were treated with decitabine,while the patients in the observation group were treated with compound Zaofan pills on this basis,4 weeks was a course of treatment,with four consecutive courses of treatment.The therapeutic efficacy and adverse reactions of the two groups were compared,and the absolute value of peripheral blood neutrophils(NEU),white blood cell count(WBC),hemoglobin,the serum tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),vascular endothelial growth factor(VEGF)and the quality of life core questionnaire(QLQ-C30)were compared between the two groups before and after treatment.Results The total remission rate in the observation group was 60.00%,which was significantly higher than that in the control group(40.00%),the total incidence of adverse reactions was 10.00%,which was significantly lower than that in the control group(28.33%),the differences were statistically significant(P<0.05).After treatment,peripheral blood NEU,WBC and Hb in both groups were increased,and the index levels in the observation group were(1.54±0.36)×10^(9)/L,(2.89±0.21)×10^(9)/L,(93.66±10.27)g/L,which were higher than those in the control group[(1.31±0.28)×10^(9)/L,(2.36±0.15)×10^(9)/L,(75.26±9.14)g/L],and the differences were statistically significant(P<0.05).After treatment,the levels of serum TNF-α,IL-6 and VEGF in both groups were lower than those before treatment,and the levels of serum TNF-ɑ,IL-6 and VEGF in the observation group were(0.89±0.21)ng/mL,(34.66±7.61)pg/mL,(182.24±15.68)ng/L,which were lowe

关 键 词：骨髓异常增生综合征 地西他滨 复方皂矾丸 治疗效果 炎症 

分 类 号：R551.3[医药卫生—血液循环系统疾病]