基于数据挖掘探讨国家专利口服中药复方治疗膝骨关节炎的用药规律  

Analysis of Medication Regularity of Oral Chinese Medicinal Compounds with National Patents in the Treatment of Knee Osteoarthritis Based on Data Mining

作　　者：袁林 贾育松 李亚锋 赵学千 刘楚吟 马慧 杨浩田 YUAN Lin;JIA Yusong;LI Yafeng;ZHAO Xueqian;LIU Chuyin;MA Hui;YANG Haotian(The First Clinical Medical School of Beijing University of Chinese Medicine,Beijing 100700,China;Graduate School of Beijing University of Chinese Medicine,Beijing 100029,China;The Second Affiliated Hospital of Tsinghua University,Beijing 100040,China)

机构地区：[1]北京中医药大学第一临床医学院,北京100700 [2]北京中医药大学研究生院,北京100029 [3]清华大学第二附属医院,北京100040

出　　处：《中药新药与临床药理》2023年第2期279-286,共8页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：北京中医药大学东直门医院2020科技创新专项(DZMKJCX-2020-057)。

摘　　要：目的 数据挖掘国家专利口服中药复方治疗膝骨关节炎(knee osteoarthritis,KOA)的用药规律,以期为临床组方遣药及新药研发提供依据。方法 检索并筛选国家知识产权公共服务网站中的中药内服治疗膝骨关节炎的复方专利相关数据,建立中药复方数据库,运用相关软件统计分析中药的使用频次、功效类别、性味归经、毒性中药用量、关联规则分析,并对关联强度较高的中药用量进行聚类分析。结果 筛选纳入的89首治疗KOA的口服中药复方,计291味中药。出现频次≥9次的中药共42味,前5味中药为当归、牛膝、威灵仙、甘草、熟地黄。毒性中药32味,使用频次较多的依次为土鳖虫、全蝎、蜈蚣。四气以温、平、寒性为主,五味以苦、辛、甘为主,归经以肝经、肾经、脾经为多。中药关联规则中支持度排前列的有全蝎-蜈蚣、威灵仙-木瓜-白芍、当归-杜仲-熟地黄、乳香-没药等;系统聚类将排前18味的中药分为3组;新处方包含当归、牛膝、威灵仙、甘草、熟地黄等。结论 中药复方专利治疗KOA以补虚药、活血化瘀药、祛风湿药为主,符合KOA虚、邪、瘀的基本病机,具有标本同治的用药特点。含有毒性中药的处方占半数以上,在保证安全的前提下,如何使用毒性药物以期增强疗效仍需进一步研究验证。本研究挖掘的核心处方内涵独活寄生汤之意,祛邪与扶正兼顾,肝肾、气血均补,为临床辨治不同证型提供了一定依据。Objective To explore the medication regularity of Chinese medicinal compounds with national patents in the treatment of knee osteoarthritis(KOA)by data mining,and to provide a basis for clinical prescription dispensing and new drug research and development. Methods The data related to Chinese medicinal compounds with national patents in the treatment of KOA were downloaded, screened, and retrieved from the public service website of national intellectual property,and a database of Chinese medicinal compound was established. We used the relevant software for statistical analysis of the use frequency, efficacy category, drug properties and meridian tropism,dosage of toxic drugs and association regularity analysis. The dosage of drugs with high correlation intension was used for clustering analysis. Results A total of 89 compounds were included,involving 291 Chinese herbs. There were 42 kinds of Chinese herbs with frequency ≥9,and the top 5 kinds of Chinese herbs were Angelica Sinensis Radix,Achyranthis Bidentatae Radix, Clematidis Radix et Rhizoma, Glycyrrhizae Radix and Rehmanniae Radix Praeparata. There were 32 toxic Chinese herbs,among them Eupolyphaga Steleophaga,Scorpio and Scolopendra are frequently used. The four natures of drugs are mainly warm,balanced,and cold. The five flavors are mainly bitter,pungent, and sweet, and the herbs attributed to the liver meridians, kidney meridians and spleen meridians.Scorpio-Scolopendra,Clematidis Radix et Rhizoma-Chaenomelis Fructus-Paeoniae Radix Alba,Angelica Sinensis Radix-Eucommiae Cortex-Rehmanniae Radix Praeparata,Olibanum-Myrrha are at the forefront of support degree in association rules. The top 18 Chinese herbs were divided into 3 groups by systematic clustering. The new prescriptions are composed of Angelica Sinensis Radix, Achyranthes Bidentata Radix, Clematidis Radix et Rhizoma, Glycyrrhizae Radix and Rehmanniae Radix Praeparata. Conclusion Chinese medicinal compounds with national patents in the treatment of KOA are mainly to replenish deficiency,promote bl

关 键 词：膝骨关节炎 中药复方 数据挖掘 用药规律 毒性中药 祛邪扶正 国家专利 

分 类 号：R285.6[医药卫生—中药学]