平脂颗粒对非酒精性脂肪肝大鼠血脂和肝脂代谢的影响  

Effect of Pingzhi granule on hepatic lipid metabolism of NAFLD in rats

作　　者：张国栋[1] 潘东明 杨辉[1] 戚欢阳 杨玲敏 连周颖 黄文传[2] 黄亦琦 Zhang Guodong;Pan Dongming;Yang Hui;Qi Huangyang;Yang Lingmin;Lian Zhouyin;Huang Wenchuan;Huang Yiqi(Xiamen Institute of Medicine,Xiamen,Fujian 361008,China)

机构地区：[1]厦门市医药研究所,厦门361008 [2]厦门市中医院,厦门361009

出　　处：《福建医药杂志》2023年第1期102-106,共5页Fujian Medical Journal

基　　金：厦门市科技局科技计划项目(3502Z20184055);福建省卫生计生委中青年骨干人才培养项目(2018ZQN95)。

摘　　要：目的 探讨平脂颗粒对非酒精性脂肪肝(NAFLD)模型大鼠的治疗作用及机制。方法 将造模成功的60只SD大鼠随机分为空白组、模型组、对照组、平脂颗粒低、中、高剂量治疗组,对照组使用当飞利肝宁胶囊悬浊液灌胃;待实验结束时检测各组大鼠肝功、血脂和抗氧化应激指标。结果 模型组血液和肝脏中的ALT、AST、TC、TG、LDL-C较空白组均升高,HDL-C明显降低(P<0.01),显示造模成功;治疗组血清和肝脏中ALT、AST、TC、TG、LDL-C的含量与模型组比较均下降(P<0.01或P<0.05),且平脂颗粒高剂量组HDL-C升高明显(P<0.05);另外与模型组比较,平脂颗粒中、高剂量治疗组血清MDA下降、SOD升高(P<0.01或P<0.05),病理学观察显示平脂颗粒组能减缓治疗组脂肪肝病变程度,肝细胞脂肪变性及炎性细胞浸润较模型组均有明显改善。结论 平脂颗粒可以通过提高肝脂和血脂代谢水平,减少肝脏过氧化损伤,对NAFDL有良好的治疗作用。Objective To investigate the effect and the mechanism of Pingzhi granules on prevention and treatment to nonalcoholic fatty liver disease in SD rats with high-fat diet.Methods Healthy SD rats without specific pathogens were fed with high-fat diet for 6 weeks to replicate NAFLD animal model.Pingzhi Granules were used for intervention, and Dangfei Liganning Capsule was used as positive control drug, which was administrated by gavage continuously.At the end of the experiment, liver function, blood lipid and antioxidant stress were detected and pathological examination was conducted.Results Compared with the control group, model group showed raising AST,ALT,TC,TG,and LDL-C both in blood lipid and liver lipid(P<0.01);Compared with the model group, a certain dose of pingzhi granules can not only reduce the body weight, liver wet weight and liver index of NAFLD rats but also regulate blood lipid and liver lipid(reducing TC,TG,LDL-C,ALT,AST(P<0.01 or P<0.05)),increasing HDL-C(P<0.05);In the treatment group of medium and high dose group, MDA content decreased and SOD content increased(P<0.01 or P<0.05). Pathological results showed that the hepatocellular steatosis and inflammatory cell infiltration in the treatment group were significantly improved compared with the model group.Conclusion Pingzhi granules have good therapeutic effects on NAFLD not only by promoting lipid metabolism and liver function, but also reducing lipid peroxidation damage.

关 键 词：非酒精性脂肪肝 平脂颗粒 大鼠 肝脂 血脂 

分 类 号：R285.5[医药卫生—中药学] R575.5[医药卫生—中医学]