中药代茶饮干预非酒精性脂肪性肝病湿热蕴结证的临床研究  

Clinical study of Chinese herb tea on non-alcoholic fatty liver disease with damp-heat accumulation type

作　　者：陈慧慧 王乾皓 陈润花[2] 王允亮[2] 张烨[2] 焦瑶 袁亚利 谢春娥[3] CHEN Hui-hui;WANG Qian-hao;CHEN Run-hua;WANG Yun-liang;ZHANG Ye;JIAO Yao;YUAN Ya-li;XIE Chun-e(Beijing University of Chinese Medicine,Beijing 100029,China;Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078,China)

机构地区：[1]北京中医药大学,北京100029 [2]北京中医药大学东方医院,北京100078 [3]北京中医药大学东方医院脾胃肝胆科,100078

出　　处：《中华中医药杂志》2023年第2期902-905,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：2019年度北京中医药大学基础科研业务费-科研创新团队项目(No.2019-JYB-TD004)。

摘　　要：目的:观察中药代茶饮干预湿热蕴结证非酒精性脂肪性肝病(NAFLD)的临床疗效。方法:选取湿热蕴结证NAFLD患者72例,随机分为对照组和治疗组,每组36例。对照组进行饮食、运动干预,治疗组在对照组基础上予中药代茶饮治疗,两组疗程均为12周。观察两组治疗前后的中医症状积分、脂肪受控衰减参数(CAP)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆固醇(TC)、甘油三酯(TG),并进行中医证候疗效评价,记录两组不良反应发生情况。结果:治疗组中医证候疗效总有效率为96.9%(31/32),显著高于对照组的92.9%(26/28)(P<0.05)。两组治疗后中医症状积分、CAP、ALT、AST、TC值均较治疗前显著下降(P<0.05),治疗组治疗后TG值较治疗前显著下降(P<0.05),且治疗组治疗后中医症状积分、CAP值显著低于对照组(P<0.05)。治疗期间两组均未见不良反应。结论:中药代茶饮可有效改善湿热蕴结证NAFLD的临床症状和肝功能,降低肝内脂肪含量及血脂水平,且安全性较高。Objective: To observe the clinical efficacy of Chinese herb tea on intervention of non-alcoholic fatty liver disease(NAFLD) with damp-heat accumulation type. Methods: A total of 72 NAFLD with damp-heat accumulation type patients were randomly divided into control group and treatment group,with 36 patients in each group. The control group received diet and exercise intervention,and the treatment group added Chinese herb tea on the basis of the control group. The course of treatment of both groups was 12 weeks. The two groups were observed traditional Chinese medicine(TCM) symptom score,controlled attenuation parameter(CAP),serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),total cholesterol(TC),triglyceride(TG) and traditional Chinese medicine syndrome before and after treatment,and the adverse reactions of the two groups. Results: There was a significant difference in overall response rate between the treatment group and the control group 96.9%(31/32) vs 92.9%(26/28)(P<0.05). After treatment,both groups had significant reductions in TCM symptom score,CAP,ALT,AST,TC(P<0.05) and the treatment group also had significant reductions in TG(P<0.05). Compared with the control group,the treatment group had significantly greater reductions in TCM symptom score,CAP(P<0.05). No adverse effects were seen in either group during the treatment period. Conclusion: Chinese herb tea can effectively improve the clinical symptoms and liver function of NAFLD with damp-heat accumulation type,reduce the hepatic fat content and blood lipid level,and have high safety.

关 键 词：非酒精性脂肪性肝病 湿热蕴结证 非酒精性脂肪性肝炎 中药代茶饮 脂肪受控衰减参数 

分 类 号：R259[医药卫生—中西医结合]