血必净注射液治疗重度急性有机磷农药中毒患者的效果  

Effects of Xuebijing injection in treatment of patients with severe acute organophosphorus pesticide poisoning

作　　者：刘瑞杰 LIU Ruijie(Zhumadian Second People’s Hospital,Zhumadian 463000 Henan,China)

机构地区：[1]驻马店市第二人民医院,河南驻马店463000

出　　处：《中国民康医学》2023年第2期65-67,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察血必净注射液治疗重度急性有机磷农药中毒(AOPP)患者的效果。方法:选取2018年7月至2020年6月该院收治的60例重度AOPP患者进行前瞻性研究,按随机数字表法将其分为对照组和观察组各30例。对照组予以常规治疗,观察组在对照组基础上予以血必净注射液治疗,比较两组治疗前后炎性因子[C反应蛋白(CRP)、白细胞介素(IL)-6、IL-1β]水平、疾病相关指标水平,以及并发症发生率。结果:治疗后,两组CRP、IL-6、IL-1β水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组阿托品用量少于对照组,胆碱酯酶活性恢复60%所需时间、住院时间均短于对照组,差异有统计学意义(P<0.05);观察组并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论:在常规治疗基础上予以血必净注射液治疗重度AOPP患者可降低炎性因子水平、疾病相关指标水平和并发症发生率,其效果优于单纯常规治疗。Objective: To observe effects of Xuebijing injection in treatment of patients with severe acute organophosphorus pesticide poisoning(AOPP). Methods: A prospective study was conducted on 60 patients with severe AOPP admitted to the hospital from July 2018 to June 2020. They were divided into control group and observation group according to the random number table method, 30 cases in each. The control group was given routine treatment, while the observation group was treated with Xuebijing injection on the basis of that of the control group.The inflammatory factor levels [C-reactive protein(CRP), interleukin(IL)-6, IL-1β], the disease-related indicator levels, and the incidence of complications were compared between the two groups before and after the treatment. Results: After the treatment, the levels of CRP, IL-6 and IL-1βin the two groups were lower than those before the treatment, those in the observation group were lower than those in the control group, and the differences were statistically significant(P<0.05). The Atropine dosage in the observation group was less than that in the control group;the time required for 60% recovery of cholinesterase activity and the hospitalization time were shorter than those in the control group;and the differences were statistically significant(P<0.05). Further, the incidence of complications in the observation group was lower than that in the control group, and the difference was statistically significant(P<0.05). Conclusions: On the basis of the routine treatment, Xuebijing injection can reduce the inflammatory factor levels, the disease-related indicator levels and the incidence of complications in the patients with severe AOPP. Moreover, it is superior to single routine treatment.

关 键 词：血必净注射液 重度 急性有机磷农药中毒 炎性因子 阿托品用量 并发症 

分 类 号：R595[医药卫生—内科学]