玉屏风颗粒联合阿奇霉素治疗肺炎支原体肺炎患儿的效果  

Effects of Yupingfeng granules combined with Azithromycin in treatment of children with mycoplasma pneumoniae pneumonia

作　　者：侯旭东[1] HOU Xudong(Department of Internal Medicine of Jiamusi City Maternal and Child Health Hospital,Jiamusi 154002 Heilongjiang,China)

机构地区：[1]佳木斯市妇幼保健院儿内科,黑龙江佳木斯154002

出　　处：《中国民康医学》2023年第2期116-119,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察玉屏风颗粒联合阿奇霉素治疗肺炎支原体肺炎(MPP)患儿的效果。方法:回顾性分析2020年1月至2022年1月该院收治的90例MPP患儿的临床资料,按照治疗方法不同将患儿分为对照组和观察组各45例。对照组采用阿奇霉素治疗,观察组在对照组基础上联合玉屏风颗粒治疗。比较两组临床疗效,临床症状体征消失时间,治疗前后肺功能指标[用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、最大通气量(MVV)]水平,血清学指标[血清淀粉样蛋白A(SAA)、人软骨糖蛋白-39(HC-gp39)、血清铁蛋白(SF)]水平,以及不良反应发生率。结果:观察组治疗总有效率为97.78%(44/45),高于对照组的82.22%(37/45),差异有统计学意义(P<0.05);观察组退热时间和咳嗽、肺啰音、肺部阴影等临床症状体征消失时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组FVC、FEV1、MVV水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组血清SAA、HC-gp39、SF水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:玉屏风颗粒联合阿奇霉素治疗MPP患儿可提高治疗总有效率和肺功能指标水平,加快症状缓解,减轻肺部炎症,效果优于单纯阿奇霉素治疗。Objective: To observe effects of Yupingfeng granules combined with Azithromycin in treatment of children with mycoplasma pneumoniae pneumonia(MPP). Methods: The clinical data of 90 children with MPP admitted to this hospital from January 2020 to January 2022were retrospectively analyzed. These children were divided into control group and observation group according to different treatment methods, 45cases in each group. The control group was treated with Azithromycin, while the observation group was treated with Yupingfeng granules on the basis of that of the control group. The clinical efficacy, the disappearance time of clinical symptoms and signs, the pulmonary function index levels [forced vital capacity(FVC), forced expiratory volume in one second(FEV1), maximum ventilation volume(MVV)], the serological index levels [serum amyloid A(SAA), human cartilage glycoprotein-39(HC-gp39), serum ferritin(SF)], and incidence of adverse reactions were compared between the two groups before and after the treatment. Results: The total effective rate of treatment in the observation group was 97.78%(44/45), which was higher than 82.22%(37/45) in the control group, and the difference was statistically significant(P<0.05). The antipyretic time and the disappearance time of clinical symptoms and signs such as cough, lung rale and lung shadow in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05). After the treatment, the levels of lung function indexes such as FVC, FEV1 and MVV in the two groups were higher than those before the treatment, those in the observation group were higher than those in the control group, and the differences were statistically significant(P<0.05). After the treatment, the levels of serum SAA, HC-gp39, SF and other serological indexes in the two groups were lower than those before the treatment, those in the observation group were lower than those in the control group, and the differences were statistically significant(P<0.05). Ho

关 键 词：玉屏风颗粒 阿奇霉素 肺炎支原体肺炎 儿童 肺功能 临床症状 不良反应 

分 类 号：R563.1[医药卫生—呼吸系统]