人参皂苷Rg1的神经保护作用研究进展  

Progress on the neuroprotective effects of ginsenoside Rg1

作　　者：龙俊鹏 孙洋 刘莎莎 姚娇 阳松威 杨岩涛[1,2] 裴刚 孟蕾[1,2] 艾启迪 陈乃宏[1,2,4] LONG Jun-peng;SUN Yang;LIU Sha-sha;YAO Jiao;YANG Song-wei;YANG Yan-tao;PEI Gang;MENG Lei;AI Qi;CHEN Nai-hong(College of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China;Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces,Changsha 410208,China;Xiangtan Central Hospital,Xiangtan 411199,China;Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)

机构地区：[1]湖南中医药大学药学院,湖南长沙410208 [2]湖南省中药饮片标准化及功能工程技术研究中心,湖南长沙410208 [3]湘潭市中心医院,湖南湘潭411199 [4]中国医学科学院、北京协和医学院药物研究所,北京100050

出　　处：《药学学报》2023年第1期21-26,共6页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(82174271);湖南省自然科学基金项目(2021JJ30512,2022JJ40456);湖南省教育厅优秀青年项目(21B0354);长沙市自然科学基金资助项目(kq2202269);湖南中医药大学校级基金重点项目(2019xjjj001);湖南中医药大学生物工程重点学科([2018]No.3);湖南中医药大学中药学一流学科建设项目。

摘　　要：人参皂苷Rg1是人参中最主要的皂苷成分之一,具有广泛的药理活性,被认为是一种强大的神经保护剂,具有抗神经炎症、抗氧化应激、抗神经凋亡和增强记忆力等神经保护作用。Rg1在防治阿尔茨海默症、帕金森病、脑卒中等神经退行性疾病及抑郁症等精神类疾病中展现出了良好的应用前景。本文就近些年国内外对Rg1的神经保护作用机制研究进行综述,旨在为临床上治疗神经系统性疾病提供新的研究思路。Ginsenoside Rg1 is one of the most important saponins in ginseng.It has a wide range of pharmacological activities.It is considered to be a powerful neuroprotective agent.It has neuroprotective effects such as antineuroinflammation,anti-oxidative stress,anti-neuronal apoptosis,and enhancing memory.Rg1 shows a good application prospect in the prevention and treatment of neurodegenerative diseases such as Alzheimer’s disease,Parkinson’s disease,stroke,and mental diseases such as depression.This paper reviews the research on the neuroprotective mechanism of Rg1 at home and abroad in recent years,in order to provide new research ideas for the clinical treatment of nervous system diseases.

关 键 词：人参皂苷RG1 神经保护 神经退行性疾病 阿尔茨海默症 脑卒中 

分 类 号：R966[医药卫生—药理学]