用于肺部疾病治疗的细胞膜涂层仿生纳米粒递送体系研究进展  

Research progress of cell membrane-coated biomimetic nanoparticle delivery systems for the treatment of lung diseases

作　　者：王钰莹 王曦 秦泓林 杨剑 WANG Yu-ying;WANG Xi;QIN Hong-lin;YANG Jian(State Key Laboratory of Component-based Chinese Medicine of Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Institute of Chinese Medicine of Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Haihe Laboratory of Modern Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学,省部共建组分中药国家重点实验室,天津301617 [2]天津中医药大学,中医药研究院,天津301617 [3]现代中医药海河实验室,天津301617

出　　处：《药学学报》2023年第1期76-85,共10页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(82074032);天津市科技计划项目(22ZXGBSY00020);天津市科委科技创新基地建设(21ZYJDJC00070)。

摘　　要：肺易受外界侵扰,造成多种急性和慢性肺部疾病。采用功能化纳米粒作为载体可携带药物穿透多重肺生理屏障进入肺病变部位,但存在靶向性差、治疗效率低等问题。细胞膜涂层仿生纳米粒作为药物载体,由于保留其源细胞特性,具有免疫系统逃逸、主动靶向、炎症趋化、穿过生理屏障等特点,近年来被大量应用于肺部疾病的治疗研究。本综述总结了近年来多种细胞膜仿生纳米粒在肺部疾病治疗中的应用,并进行了分类论述,其中细胞膜来源包括红细胞膜、血小板膜、巨噬细胞膜、中性粒细胞膜、肺上皮细胞膜、肺表面活性剂、内皮细胞膜、癌细胞膜、细菌膜和混合膜等。本综述旨在为细胞膜涂层仿生纳米粒治疗肺部疾病提供新思路。Lung is susceptible to external disturbance,resulting in a variety of acute and chronic lung diseases.Functionalized nanoparticles as carriers can carry drugs through multiple biological barriers of lung into lung lesions,but there are some problems such as poor targeting and low therapeutic efficiency.As a drug carrier,membranecoated biomimetic nanoparticles have the characteristics of immune system escape,active targeting,inflammatory chemotaxis and crossing physiological barriers due to the retention of the characteristics of the source cells.Therefore,it has been widely used in the treatment of lung diseases in recent years.In this review,the application of membrane-coated biomimetic nanoparticles in the treatment of lung diseases in the recent years was summarized and classified.Cell membrane sources include erythrocyte membrane,platelet membrane,macrophage membrane,neutrophil membrane,lung epithelial membrane,lung surfactant,endothelial membrane,cancer cell membrane,bacterial membrane,hybrid membrane and so on.The purpose of this review is to provide a new idea for treating lung diseases with membrane-coated biomimetic nanoparticles.

关 键 词：细胞膜涂层 仿生纳米粒 药物递送系统 肺部疾病 生理屏障 免疫逃逸 

分 类 号：R945[医药卫生—微生物与生化药学]