Novel 3D printed shape-memory PLLA-TMC/GA-TMC scaffolds for bone tissue engineering with the improved mechanical properties and degradability  

作　　者：Xulin Hu Weiming Zhao Zhen Zhang Jianping Xie Jian He Jianfei Cao Qing Li Yajing Yan Chengdong Xiong Kainan Li 

机构地区：[1]Clinical Medical College&Affiliated Hospital of Chengdu University,Chengdu University,Chengdu 610081,China [2]Chengdu Institute of Organic Chemistry,Chinese Academy of Sciences,Chengdu 610041,China [3]University of Chinese Academy of Sciences,Beijing 100049,China [4]College of Medical,Henan University of Science and Technology,Luoyang 471023,China [5]School of Materials and Environmental Engineering,Chengdu Technological University,Chengdu 610031,China

出　　处：《Chinese Chemical Letters》2023年第1期221-224,共4页中国化学快报（英文版）

基　　金：the sub project of the national major project generation method and application verification of personalized rehabilitation prescription for patients with balance(No.2019YFB1311403)。

摘　　要：The biodegradable substitution materials for bone tissue engineering have been a research hotspot.As is known to all,the biodegradability,biocompatibility,mechanical properties and plasticity of the substitution materials are the important indicators for the application of implantation materials.In this article,we reported a novel binary substitution material by blending the poly(lactic-acid)-co-(trimethylenecarbonate)and poly(glycolic-acid)-co-(trimethylene-carbonate),which are both biodegradable polymers with the same segment of flexible trimethylene-carbonate in order to accelerate the degradation rate of poly(lactic-acid)-co-(trimethylene carbonate)substrate and improve its mechanical properties.Besides,we further fabricate the porous poly(lactic-acid)-co-(trimethylene-carbonate)/poly(glycolic-acid)-co-(trimethylene-carbonate)scaffolds with uniform microstructure by the 3D extrusion printing technology in a mild printing condition.The physicochemical properties of the poly(lactic-acid)-co-(trimethylenecarbonate)/poly(glycolic-acid)-co-(trimethylene-carbonate)and the 3D printing scaffolds were investigated by universal tensile dynamometer,fourier transform infrared reflection(FTIR),scanning electron microscope(SEM)and differential scanning calorimeter(DSC).Meanwhile,the degradability of the PLLATMC/GA-TMC was performed in vitro degradation assays.Compared with PLLA-TMC group,PLLA-TMC/GATMC groups maintained the decreasing Tg,higher degradation rate and initial mechanical performance.Furthermore,the PLLA-TMC/GA-TMC 3D printing scaffolds provided shape-memory ability at 37℃.In summary,the PLLA-TMC/GA-TMC can be regarded as an alternative substitution material for bone tissue engineering.

关 键 词：Bone scaffolds Biodegradable polymers 3D printed Shape memory Tissue engineering 

分 类 号：R68[医药卫生—骨科学]