Au-catalyzed neighboring hydroxymethyl group directed cycloaddition of alkyne with diazadienes:Synthesis of polysubstituted pyrroles  

作　　者：Zhenwei Shi Wenxiu Mao Zhenning Yang Shuzhe Sun Chen-Ho Tung Zhenghu Xu 

机构地区：[1]School of Chemistry and Chemical Engineering,Shandong University,Ji’nan 250100,China [2]Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province,School of Science,Westlake University,Hangzhou 310024,China

出　　处：《Chinese Chemical Letters》2023年第1期342-346,共5页中国化学快报（英文版）

基　　金：the financial support from the Natural Science Foundation of China and Shandong Province(Nos.21971149,92156007,ZR2019ZD45,ZR2020KB005);the Fundamental Research Funds of Shandong University。

摘　　要：Polysubstituted pyrroles are very important scaffolds in many bioactive natural products and synthetic pharmaceuticals.Here,a new gold-catalyzed cycloaddition of alkynes with azadienes to access tetrasubstituted pyrroles is demonstrated.The neighboring hydroxylmethyl group serves a very important directing group through an addition/cycloaddition/elimination cascade.Diverse polysubstituted pyrroles were synthesized in good yields under mild conditions in one step,and tricyclic pyrrole containing heterocycles were easily obtained through derivatization.

关 键 词：PYRROLE AU Neighboring group Cascade reaction Synthetic method 

分 类 号：O626[理学—有机化学]