Host-guest interactions based supramolecular complexes self-assemblies for amplified chemodynamic therapy with H_(2)O_(2) elevation and GSH consumption properties  

作　　者：Yang Bai Yujie Pan Na An Haitao Zhang Chao Wang Wei Tian Tao Huang 

机构地区：[1]Shaanxi Key Laboratory of Chemical Additives for Industry,College of Chemistry and Chemical Engineering,Shaanxi University of Science and Technology,Xi’an 710021,China [2]School of Light Industry Science and Engineering,Qilu University of Technology,Shandong Academy of Sciences,Ji’nan 250353,China [3]MOE Key Laboratory of Material Physics and Chemistry under Extraordinary Conditions,School of Chemistry and Chemical Engineering,Northwestern Polytechnical University,Xi’an 710072,China

出　　处：《Chinese Chemical Letters》2023年第1期367-372,共6页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.21801162,22071197,22022107);Natural Science Basic Research Plan in Shaanxi Province of China(No.2020JC20)。

摘　　要：Although endogenous H_(2)O_(2) is overexpressed in tumor tissue,the amount of endogenous H_(2)O_(2) is still insufficient for chemodynamic therapy(CDT).In addition,the abundant cellular glutathione(GSH)could also consume·OH for reduced CDT.Thus,the elevation of H_(2)O_(2) and the consumption of GSH in tumor tissue are essential for the increased·OH yield and amplified CDT efficacy.In this paper,hostguest interactions based supramolecular complexes self-assemblies(SCSAs)were fabricated by incorporating cinnamaldehyde(CA)and PEG-modified cyclodextrin host units(m PEG-CD-CA)with ferrocene-(phenylboronic acid pinacol ester)conjugates(Fc-BE)on the basis of CD-induced host-guest interactions.After being internalized by cancer cells,CA can be released from SCSAs through the p H-responsive acetal linkage,elevating the H2O2level by activating NADPH oxidase.Then,Fc can catalyze the H_(2)O_(2) to higher cytotoxic hydroxyl radicals(·OH).Moreover,quinone methide(QM)can be produced through H_(2)O_(2)-induced aryl boronic ester rearrangement and further consume the antioxidant GSH.In vitro and in vivo experiments demonstrate that SCSAs can be provided as potential amplified CDT nanoagents.

关 键 词：CYCLODEXTRIN Host-guest inclusion interactions Chemodynamic therapy 

分 类 号：O641.4[理学—物理化学]