Self-assembly behavior of disaccharide-containing supra-amphiphiles  

作　　者：Zhenfei Gao Tiannan Wang Zikun Rao Hui Yan Ran Zhang Guosong Chen 

机构地区：[1]The State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science,Fudan University,Shanghai 200433,China [2]Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China [3]School of Pharmaceutical Sciences,Liaocheng University,Liaocheng 252059,China

出　　处：《Chinese Chemical Letters》2023年第1期373-377,共5页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(NSFC,Nos.52125303,51721002,91956127 and 21975047)for financial support;the National Natural Science Foundation of China(NSFC,Nos.21674114 and 91956127)for financial support;supported by the Shanghai Municipal Science and Technology Major Project(No.2018SHZDZX01);ZJ Lab。

摘　　要：In this paper,supra-amphiphilic compounds containing disaccharides and azobenzene ends have been constructed via dynamic covalent bond.It was found that the slight structural difference of the disaccharides made significant difference in the self-assembled morphologies.Namely,three kinds of azodisaccharide supra-amphiphiles were found to assemble into different morphologies,with the only difference in chemical structure from the disaccharides.More importantly,the structural difference between the disaccharides,including lactoside,maltoside and cellobioside was trivial.Molecular simulation revealed the packing of molecules was due to the different contribution from hydrogen bonds.The above results clearly indicated the contribution of saccharide packing,especially the related hydrogen bonding,to the final morphology of the assembled structures.

关 键 词：Supra-amphiphile DISACCHARIDE Self-assembly Dynamic covalent bond Molecular dynamics simulation 

分 类 号：O641.3[理学—物理化学]