喜马拉雅旱獭自然感染鼠疫耶尔森菌后部分脏器病理变化的研究  

Pathological changes of some organs of Marmota himalayana naturally infected with Yersinia pestis

作　　者：张芃 周永运[2] 吕东月 贺兆锴 段然[1] 秦帅 汤德铭 肖萌 景怀琦[1] 王鑫[1] ZHANG Peng;ZHOU Yong-yun;LYU Dong-yue;HE Zhao-kai;DUAN Ran;QIN Shuai;TANG De-ming;XIAO Meng;JING Huai-qi;WANG Xin(Emergency Response Laboratory,National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China;China National Accreditation Service for Conformity Assessment,Beijing 100062,China;Shanghai Pudong New Area Center for Disease Control and Prevention,Shanghai 200120,China;Hangzhou Center for Disease Control and Prevention,Hangzhou,Zhejiang 310021,China)

机构地区：[1]中国疾病预防控制中心传染病预防控制所应急实验室,北京102206 [2]中国合格评定国家认可中心,北京100062 [3]上海市浦东新区疾病预防控制中心,上海200120 [4]杭州市疾病预防控制中心,浙江杭州310021

出　　处：《中国媒介生物学及控制杂志》2023年第1期9-13,共5页Chinese Journal of Vector Biology and Control

基　　金：国家科技重大专项(2018ZX10713-001-002,2018ZX10713-003-002)。

摘　　要：目的了解喜马拉雅旱獭(旱獭)自然感染鼠疫耶尔森菌(鼠疫菌)所导致的脾质量和主要脏器的组织病理变化,揭示鼠疫的致病特点。方法分析2020-2021年获得的活体旱獭及自毙旱獭脾质量与体质量的比值,取正常旱獭以及感染鼠疫菌自毙旱獭的肝、肺、脾脏3种器官制作病理切片,并观察组织病理学变化。结果感染鼠疫菌的自毙旱獭脾质量与体质量的比值明显高于未感染鼠疫菌的旱獭,且差异有统计学意义(χ^(2)=33.144,P<0.001)。感染鼠疫菌自毙旱獭的肝、肺、脾脏均有细胞形态被破坏,炎性细胞浸润,血管扩张等炎症病变,脾脏的血管损伤和红髓白髓的变化更为明显。结论鼠疫菌可引起旱獭机体产生严重的炎症反应,脾脏的病变对于探讨鼠疫菌的致病过程和机制更具研究意义。Objective To investigate the weight of spleen and the histopathological changes of main organs caused by natural infection of Yersinia pestis in Marmota himalayana(marmot),and to reveal the pathogenic characteristics of plague.Methods The ratio of spleen weight to body weight of living marmots and self-dead marmots obtained from 2020 to 2021 was analyzed.The liver,lung,and spleen of normal marmots and self-dead marmots infected with Y.pestis were collected to make pathological sections for observing histopathological changes.Results The ratio of spleen weight to body weight of self-dead marmots infected with Y.pestis was statistically greater than that of marmots not infected with Y.pestis(χ^(2)=33.144,P<0.001).In the liver,lung,and spleen of self-dead marmots infected with Y.pestis,there were cell morphology destruction,inflammatory cell infiltration,vasodilation,and other inflammatory lesions,and vascular injury of the spleen and changes in the red pulp and white pulp were more significant.Conclusion Y.pestis can cause serious inflammatory reaction in marmots,and the pathological changes of the spleen are of more significance for study of the pathogenic process and mechanism of Y.pestis.

关 键 词：鼠疫 喜马拉雅旱獭 病理学 

分 类 号：R516.8[医药卫生—内科学]