氟尿嘧啶类药物诱导心脏毒性研究进展  

Cardiactoxicity Induced by Fluorouracil:Research Advances

作　　者：刘子祺 许杰 杜艳红 贾连玲 赵玉涓 赵瑞君 宋云龙 LIU Zi-qi;XU Jie;DU Yan-hong;JIA Lian-ling;ZHAO Yu-juan;ZHAO Rui-jun;SONG Yun-long(Rocket Force Characteristic Medical Center of PLA,Beijing 100088,China)

机构地区：[1]火箭军特色医学中心,北京100088

出　　处：《解放军药学学报》2023年第1期83-89,共7页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：氟尿嘧啶类药物诱导心脏毒性是患者进行含氟尿嘧啶类药物治疗中诱发的心脏毒性,是一种抗肿瘤治疗过程中严重的并发症,较为少见,对肿瘤患者的预后和生存有显著影响。随着氟尿嘧啶类药物的广泛应用,其心脏毒性也日益受到重视。本文主要对氟尿嘧啶类药物诱导心脏毒性的临床表现、发生率、可能机制、预测方法、救治药物和治疗方案、替代治疗等研究进展进行综述。Fluorouracil-induced cardiotoxicity(FIC)is the cardiotoxicity induced by fluorouracil-containing drugs during treatment,which is a rare but serious complication during antitumor chemotherapy that impacts the prognosis and survival of cancer patients.With the wider application of fluorouracil,its cardiotoxicity is attracting more attention.In this paper,the clinical manifestations,incidence,possible mechanisms,prediction methods,therapeutic agents and treatment regimens,and alternative therapies of fluorouracil-induced cardiotoxicity were reviewed.

关 键 词：氟尿嘧啶 心脏毒性 5-氟尿嘧啶 卡培他滨 

分 类 号：R969[医药卫生—药理学]