肝脏NK细胞亚群的异质性  

Heterogeneity of liver NK cells

作　　者：陈雅雯 田志刚[1,2] 彭慧 CHEN YaWen;TIAN ZhiGang;PENG Hui(Institute of Immunology,University of Science and Technology of China,Hefei 230027,China;ResearchUnitof NKCell Study,ChineseAcademyof Medical Sciences,Hefei230027,China)

机构地区：[1]中国科学技术大学免疫学研究所,合肥230027 [2]中国医学科学院创新单元,合肥230027

出　　处：《中国科学：生命科学》2023年第2期250-261,共12页Scientia Sinica(Vitae)

基　　金：国家自然科学基金(批准号:81788101,81922029,91542000);国家重点研发计划(批准号:2020YFA0804100);NK细胞研究创新单元(批准号:2019-I2M-5-073)资助。

摘　　要：自然杀伤(natural killer,NK)细胞自20世纪70年代被发现以来备受关注,但早期研究多以循环NK细胞作为研究对象.直到近十年,NK细胞的组织异质性才受到学界重视.肝脏作为NK细胞含量丰富且异质性的器官,为研究NK细胞亚群提供了很好的窗口.肝脏NK细胞由参与血液循环的经典NK细胞和肝脏驻留NK细胞组成,本文重点介绍肝脏驻留NK细胞与经典NK细胞在发育起源、分化、转录调控、免疫功能等方面的差异,以期为肝脏区域免疫特性研究提供新的切入点.Natural killer(NK)cells have attracted much attention since their discovery in the 1970s;however,earlier studies mainly focused on circulating NK cells.In the past decade,the heterogeneity of NK cells in different tissues has begun to attract increasing attention.As an organ containing abundant and heterogeneous NK cell populations,the liver provides a good window for studying them.It is now commonly accepted that bulk liver NK cells comprise circulating conventional NK cells and liver-resident NK cells.This review summarized and discussed the developmental origin,differentiation,transcriptional regulation,and immune functions of liverresident NK cells and conventional NK cells,providing new perspectives for studying liver regional immunity.

关 键 词：肝脏驻留NK细胞 经典NK细胞 发育起源 转录因子 病毒感染 肝细胞癌 

分 类 号：R392[医药卫生—免疫学]