抗菌药物增效剂的前沿研究进展  

Recent advances in the development of antibacterial potentiators

作　　者：郑绩 王辉[1] Zheng Ji;Wang Hui(Department of Clinical Laboratory,Peking University People′s Hospital,Beijing 100044,China)

机构地区：[1]北京大学人民医院检验科,北京100044

出　　处：《中华检验医学杂志》2023年第2期218-224,共7页Chinese Journal of Laboratory Medicine

基　　金：国家重点研发计划(2018YFE0102100)。

摘　　要：细菌对抗菌药物的耐药性已发展成为一场全球性医疗危机,最终出现了无法用任何普通抗菌药物治疗的多药耐药细菌。因此,迫切需要新型抗菌增效剂,使细菌重新恢复对抗菌药物的敏感性。本文旨在对新颖的抗菌增效方法及其背后的机制、临床实验数据及疗效、药物研发管线的进展进行综述,以期提高对抗菌药物增效剂的认识。Multidrug-resistant bacteria that can′t be treated with any common antibacterial drugs have become a global medical crisis.Therefore,there is an urgent need for new antibacterial potentiators to restore the sensitivity of bacteria to the antibacterial drug.This review elaborates on the novel antibacterial synergistic methods and their underlying mechanisms,clinical experimental data and efficacy,and the progress of drug research and development.This review aims to raise awareness about antibacterial potentiators among the public.

关 键 词：抗药性 多药 增效剂 外膜透化剂 Β内酰胺酶抑制剂 外排泵抑制剂 

分 类 号：R978[医药卫生—药品]