建立ICP-MS的血铅参考方法可提高检测准确性  

ICP-MS establishes blood lead reference method expected to improve detection accuracy

作　　者：许蒙雨 周伟燕[1] 邓宇航 曾洁[1] 张传宝[1] Xu Mengyu;Zhou Weiyan;Deng Yuhang;Zeng Jie;Zhang Chuanbao(National Center for Clinical Laboratories,Institude of Geriatric Medicine,Chinese Academy of Medical Science,Beijing Hosptial/National Center of Gerontology,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China)

机构地区：[1]北京医院、国家老年医学中心,国家卫生健康委临床检验中心,中国医学科学院老年医学研究院、中国医学科学院北京协和医学院,北京100730

出　　处：《中华检验医学杂志》2023年第2期225-230,共6页Chinese Journal of Laboratory Medicine

基　　金：北京自然科学基金(7212087)。

摘　　要：铅中毒以蓄积性和持久性,严重威胁着人类健康。血液中铅元素的检测不仅对铅中毒的筛查、诊断、治疗、预后判断有着重要作用,也可以间接监测环境中铅元素水平。尽管血铅的检测项目在国内开展广泛,但检测结果的准确性和可比性不佳,有多种因素可影响血铅的准确检测。为了促进铅元素检测在临床和生物监测中的应用并降低结果的偏倚,应建立血铅检测的参考方法来评价常规方法准确性,完善参考系统来推进血铅检测标准化进程,实现血铅的准确检测。Lead poisoning severely threatens human health with its cumulation and durability in the body.The analysis of lead in blood is vital for screening,diagnosis,treatment,and prognostication of lead poisoning and for indirectly monitoring the level of lead in the environment.Although the detection programs are available throughout our country,the accuracy and comparability of the results cannot meet the expectation.A variety of factors can affect the accuracy of blood lead testing.To promote the application of blood lead analysis in clinical trials and reduce the bias of results,a better reference system for blood lead analysis should be established to evaluate the accuracy of traditional methods,promote the standardization of blood lead analysis and achieve accurate blood lead testing.

关 键 词：铅中毒 参考标准 电感耦合等离子质谱法 环境监测 

分 类 号：R446.1[医药卫生—诊断学]